Functional polymorphisms of interleukin-18 gene and risk of breast cancer in a Brazilian population

被引：20
作者：
Back, L. K. D. C. [1 ,2 ]
Farias, T. D. J. [1 ]
da Cunha, P. A. [1 ]
Muniz, Y. C. N. [1 ]
Ribeiro, M. C. M. [1 ]
Fernandes, B. L. [3 ,4 ]
Fernandes, C. K. [2 ]
de Souza, I. R. [1 ]
机构：
[1] Univ Fed Santa Catarina, Dept Biol Embriol & Genet UFSC BEG, Florianopolis, SC, Brazil
[2] Biogenetika, Mol Diagnost, Florianopolis, SC, Brazil
[3] Univ Fed Santa Catarina, Hosp Univ HU UFSC, Florianopolis, SC, Brazil
[4] Hosp & Maternidade Carmela Dutra, Mastol, Florianopolis, SC, Brazil
来源：
TISSUE ANTIGENS | 2014年 / 84卷 / 02期
关键词：
breast cancer; interleukin-18; polymorphisms; PROMOTER POLYMORPHISMS; IFN-GAMMA; IL-18; SUSCEPTIBILITY; ASSOCIATION; CYTOKINE; CELLS; INFLAMMATION; CLONING;
D O I：
10.1111/tan.12367
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Interleukin-18 (IL-18) is a key cytokine responsible for immune response and involved in the process of cancer development. In this case-control study, we tested whether IL-18 promoter polymorphism contributes to breast cancer susceptibility in Brazilian patients. The two groups studied were 154 patients with breast cancer and 118 healthy individuals. The frequency of IL-18 promoter single nucleotide polymorphisms (SNPs) at positions -607 (C/A) (rs1946518) and -137 (G/C) (rs187238) was determined by polymerase chain reaction analyses. The polymorphisms genotyped in this study showed a significant association with breast cancer under different genetic models. Both SNPs showed a positive association. For the IL18-607 polymorphism the best model was the codominant genetic model [CC vs AA, P = 0.004, odds ratio (OR) = 2.782, 95% confidence interval (CI) 1.385-5.589]. For IL18-137 statistical significance was found using the recessive genetic model (P = 0.008, OR = 3.896, 95% CI 1.427-10.639). The association between the haplotypes of the IL18 gene and breast cancer was further confirmed. Our results suggest that IL18-607 and IL18-137 polymorphism contributes to increase the breast cancer risk. To our knowledge, this is the first report regarding Brazilian breast cancer patients and IL18 promoter polymorphisms.
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页码：229 / 233
页数：5
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