ER Stress and Angiogenesis

被引：151

作者：

Binet, Francois ^{[1
,2
]}

Sapieha, Przemyslaw ^{[1
,2
,3
]}

机构：

[1] Univ Montreal, Maisonneuve Rosemont Hosp Res Ctr, Dept Ophthalmol, Dept Biochem, Montreal, PQ H1T 2M4, Canada

[2] Univ Montreal, Maisonneuve Rosemont Hosp Res Ctr, Dept Mol Med, Montreal, PQ H1T 2M4, Canada

[3] McGill Univ, Dept Neurol Neurosurg, Montreal, PQ H3A 2B4, Canada

来源：

CELL METABOLISM | 2015年 / 22卷 / 04期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

UNFOLDED-PROTEIN-RESPONSE; ENDOPLASMIC-RETICULUM STRESS; ENDOTHELIAL-CELL METABOLISM; GLUCOSE-REGULATED PROTEINS; NITRIC-OXIDE SYNTHASE; DIABETIC-RETINOPATHY; GENE-EXPRESSION; MOLECULAR-MECHANISMS; MESSENGER-RNA; TRANSCRIPTIONAL INDUCTION;

D O I：

10.1016/j.cmet.2015.07.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proper tissue vascularization is vital for cellular function as it delivers oxygen, nutrients, hormones, and immune cells and helps to clear cellular debris and metabolic waste products. Tissue angiogenesis occurs to satisfy energy requirements and cellular sensors of metabolic imbalance coordinate vessel growth. In this regard, the classical pathways of the unfolded protein response activated under conditions of ER stress have recently been described to generate angiomodulatory or angiostatic signals. This review elaborates on the link between angiogenesis and ER stress and discusses the implications for diseases characterized by altered vascular homeostasis, such as cancer, retinopathies, and atherosclerosis.

引用

收藏

页码：560 / 575

页数：16

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