Roussoella percutanea, a novel opportunistic pathogen causing subcutaneous mycoses

被引：32

作者：

Ahmed, Sarah A. ^{[1
,2
,3
]}

Stevens, David A. ^{[4
,5
]}

van de Sande, Wendy W. J. ^{[6
]}

Meis, Jacques F. ^{[7
,8
]}

de Hoog, G. S. ^{[2
,3
,9
,10
,11
,12
,13
]}

机构：

[1] Univ Khartoum, Fac Med Lab Sci, Khartoum, Sudan

[2] Fungal Biodivers Ctr, Cent Bur Schimmelcultures KNAW, Utrecht, Netherlands

[3] Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, NL-1012 WX Amsterdam, Netherlands

[4] Calif Inst Med Res, San Jose, CA 95128 USA

[5] Stanford Univ, Dept Med, Sch Med, Div Infect Dis, Stanford, CA 94305 USA

[6] Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands

[7] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands

[8] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands

[9] Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China

[10] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China

[11] Second Mil Med Univ, Changzheng Hosp, Shanghai Inst Med Mycol, Shanghai, Peoples R China

[12] Univ Fed Parana, Basic Pathol Dept, Curitiba, Parana, Brazil

[13] King Abdulaziz Univ, Jeddah 21413, Saudi Arabia

来源：

MEDICAL MYCOLOGY | 2014年 / 52卷 / 07期

关键词：

Roussoella; Pleosporales; subcutaneous mycosis; phylogeny; antifungal susceptibility; ANTIFUNGAL AGENTS; IDENTIFICATION; MOLDS; GENUS; DNA;

D O I：

10.1093/mmy/myu035

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report the isolation of a novel agent of subcutaneous mycosis from a 45-year-old Indian male immigrant in the United States. Phylogenetic analysis of partial small ribosomal subunit and large ribosomal subunit, internal transcribed spacer, partial translation elongation factor (TEF1), and RNA polymerase second largest subunit (rPB2) loci revealed that the strain was identical to another isolate previously reported as "Madurella mycetomatis." Both strains clustered in the order Pleosporales, nested in the family Arthopyreniaceae/Roussoellaceae. The fungus differed from known species and hence a new taxon, Roussoella percutanea, is introduced, typified by a strain that showed delayed production of pycnidial conidiomata. Antifungal susceptibility testing suggested that the new species is resistant to echinocandins and flucytosine, with variable results with azoles and amphotericin B.

引用

页码：689 / 698

页数：10

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