Cisplatin and its analogues induce a significant change in the higher-order structure of long duplex DNA

被引：11

作者：

Katsuda, Yousuke ^{[2
]}

Yoshikawa, Yuko ^{[1
]}

Sato, Takaji ^{[2
]}

Saito, Yoshihiro ^{[2
]}

Chikuma, Masahiko ^{[2
]}

Suzuki, Mari ^{[3
,4
]}

Yoshikawa, Kenichi ^{[3
,4
]}

机构：

[1] Int Pacific Univ, Fac Educ Future Generat, Okayama 7090863, Japan

[2] Osaka Univ Pharmaceut Sci, Lab Bioanalyt Chem, Takatsuki, Osaka 5691094, Japan

[3] Kyoto Univ, Grad Sch Sci, Dept Phys, Kyoto 6068502, Japan

[4] JST, ICORP, Spatiotemporal Order Project, Kyoto 6068502, Japan

来源：

CHEMICAL PHYSICS LETTERS | 2009年 / 473卷 / 1-3期

关键词：

ANTITUMOR-ACTIVITY; PLATINUM; TRANSITION; RECOGNITION; OXALIPLATIN; COMPLEXES; ADDUCTS;

D O I：

10.1016/j.cplett.2009.03.026

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

It has recently become clear that a long DNA with a size of more than several tens of kilo base-pairs (kbp) exhibits a large on/off change in conformation between elongated coil and folded compact states. To explore the possible effect of anticancer drugs on the conformation of large DNA, we observed single DNA molecules with regard to changes in their higher-order structure upon the addition of cisplatin and its derivatives, diamminedinitratoplatinum(II) and tetrammineplatinum(II). We found that these cisplatin analogues significantly affected the conformation of individual DNA molecules by inducing a folding transition. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：155 / 159

页数：5

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