A Simple Green Protocol for the Condensation of Anthranilic Hydrazide with Cyclohexanone and N-Benzylpiperidinone in Water

被引：5

作者：

Miklos, Ferenc ^{[1
]}

Fueloep, Ferenc ^{[1
,2
]}

机构：

[1] Univ Szeged, Inst Pharmaceut Chem, Eotvos Utca 6, H-6720 Szeged, Hungary

[2] Univ Szeged, Hungarian Acad Sci, Stereochem Res Grp, Eotvos Utca 6, H-6720 Szeged, Hungary

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2016年 / 53卷 / 01期

关键词：

ANTITHROMBOTIC AGENTS M58163; DYNAMIC KINETIC RESOLUTION; 1-ARYLSULFONYL-3-PIPERAZINONE DERIVATIVES; ONE-POT; ACID; KETONES; INHIBITORS; HETEROCYCLES; CHEMISTRY; SERIES;

D O I：

10.1002/jhet.1844

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An environmentally benign condensation of anthranilic hydrazide with cyclohexanone or N-benzylpiperidin-4-one in aqueous medium has been developed for the synthesis of benzoylhydrazones A. The thermal rearrangements of hydrazones A yielded 3-aminospiro-quinazolinones B. When A or B was reacted repeatedly with cyclohexanone or N-benzylpiperidin-4-one, spiroquinazoline-hydrazones C were formed. From aqueous suspensions, products could be isolated in high purity by simple filtration.

引用

页码：32 / 37

页数：6

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