Lectins

被引:229
作者
Vijayan, M [1 ]
Chandra, N
机构
[1] Indian Inst Sci, Mol Biophys Unit, Bangalore 560012, Karnataka, India
[2] Indian Inst Sci, Bioinformat Ctr, Bangalore 560012, Karnataka, India
关键词
D O I
10.1016/S0959-440X(99)00034-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lectins - carbohydrate-binding proteins involved in a variety of recognition processes - exhibit considerable structural diversity. Three new:lectin folds and further elaborations of known folds have been described recently Large variability in quaternary association resulting from small alterations in essentially the same tertiary structure is a properly exhibited specially by legume:lectins, The strategies used by lectins to generate carbohydrate specificity include the extensive use of water bridges, post-translational modification and oligomerisation. Recent results pertaining to influenza and foot-and-mouth viruses further elaborate the role of lectins in infection.
引用
收藏
页码:707 / 714
页数:8
相关论文
共 59 条
[41]   Preferred conformation of C-lactose at the free and peanut lectin bound states [J].
Ravishankar, R ;
Surolia, A ;
Vijayan, M ;
Lim, S ;
Kishi, Y .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (44) :11297-11303
[42]  
RAVISHANKAR R, 1999, CURR SCI, V76, pB93
[43]   New animal lectin structures [J].
Rini, JM ;
Lobsanov, YD .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1999, 9 (05) :578-584
[44]   Molecular basis of lysosomal enzyme recognition: Three-dimensional structure of the cation-dependent mannose 6-phosphate receptor [J].
Roberts, DL ;
Weix, DJ ;
Dahms, NM ;
Kim, JJP .
CELL, 1998, 93 (04) :639-648
[45]   Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus [J].
Rosenthal, PB ;
Zhang, XD ;
Formanowski, F ;
Fitz, W ;
Wong, CH ;
Meier-Ewert, H ;
Skehel, JJ ;
Wiley, DC .
NATURE, 1998, 396 (6706) :92-96
[46]   Crystal structure of the lectin from Dioclea grandiflora complexed with core trimannoside of asparagine-linked carbohydrates [J].
Rozwarski, DA ;
Swami, BM ;
Brewer, CF ;
Sacchettini, JC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (49) :32818-32825
[47]   A novel mode of carbohydrate recognition in jacalin, a Moraceae plant lectin with a beta-prism fold [J].
Sankaranarayanan, R ;
Sekar, K ;
Banerjee, R ;
Sharma, V ;
Surolia, A ;
Vijayan, M .
NATURE STRUCTURAL BIOLOGY, 1996, 3 (07) :596-603
[48]   Insights into carbohydrate recognition by Narcissus pseudonarcissus lectin:: The crystal structure at 2 Å resolution in complex with α1-3 mannobiose [J].
Sauerborn, MK ;
Wright, LM ;
Reynolds, CD ;
Grossmann, JG ;
Rizkallah, PJ .
JOURNAL OF MOLECULAR BIOLOGY, 1999, 290 (01) :185-199
[49]   X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-Å resolution [J].
Seetharaman, J ;
Kanigsberg, A ;
Slaaby, R ;
Leffler, H ;
Barondes, SH ;
Rini, JM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (21) :13047-13052
[50]   STRUCTURE OF A LEGUME LECTIN WITH AN ORDERED N-LINKED CARBOHYDRATE IN COMPLEX WITH LACTOSE [J].
SHAANAN, B ;
LIS, H ;
SHARON, N .
SCIENCE, 1991, 254 (5033) :862-866