Lectins

被引:227
作者
Vijayan, M [1 ]
Chandra, N
机构
[1] Indian Inst Sci, Mol Biophys Unit, Bangalore 560012, Karnataka, India
[2] Indian Inst Sci, Bioinformat Ctr, Bangalore 560012, Karnataka, India
关键词
D O I
10.1016/S0959-440X(99)00034-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lectins - carbohydrate-binding proteins involved in a variety of recognition processes - exhibit considerable structural diversity. Three new:lectin folds and further elaborations of known folds have been described recently Large variability in quaternary association resulting from small alterations in essentially the same tertiary structure is a properly exhibited specially by legume:lectins, The strategies used by lectins to generate carbohydrate specificity include the extensive use of water bridges, post-translational modification and oligomerisation. Recent results pertaining to influenza and foot-and-mouth viruses further elaborate the role of lectins in infection.
引用
收藏
页码:707 / 714
页数:8
相关论文
共 59 条
[1]   CRYSTAL-STRUCTURE OF PEANUT LECTIN, A PROTEIN WITH AN UNUSUAL QUATERNARY STRUCTURE [J].
BANERJEE, R ;
MANDE, SC ;
GANESH, V ;
DAS, K ;
DHANARAJ, V ;
MAHANTA, SK ;
SUGUNA, K ;
SUROLIA, A ;
VIJAYAN, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (01) :227-231
[2]   Conformation, protein-carbohydrate interactions and a novel subunit association in the refined structure of peanut lectin-lactose complex [J].
Banerjee, R ;
Das, K ;
Ravishankar, R ;
Suguna, K ;
Surolia, A ;
Vijayan, M .
JOURNAL OF MOLECULAR BIOLOGY, 1996, 259 (02) :281-296
[3]  
BECKER JW, 1975, J BIOL CHEM, V250, P1513
[4]   Tachylectin-2:: crystal structure of a specific GlcNAc/GalNAc-binding lectin involved in the innate immunity host defense of the Japanese horseshoe crab Tachypleus tridentatus [J].
Beisel, HG ;
Kawabata, S ;
Iwanaga, S ;
Huber, R ;
Bode, W .
EMBO JOURNAL, 1999, 18 (09) :2313-2322
[5]   Novel structures of plant lectins and their complexes with carbohydrates [J].
Bouckaert, J ;
Hamelryck, T ;
Wyns, L ;
Loris, R .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1999, 9 (05) :572-577
[6]   Structure of CD94 reveals a novel C-type lectin fold: Implications for the NK cell-associated CD94/NKG2 receptors [J].
Boyington, JC ;
Riaz, AN ;
Patamawenu, A ;
Coligan, JE ;
Brooks, AG ;
Sun, PD .
IMMUNITY, 1999, 10 (01) :75-82
[7]   X-ray and molecular dynamics studies of concanavalin-A glucoside and mannoside complexes - Relating structure to thermodynamics of binding [J].
Bradbrook, GM ;
Gleichmann, T ;
Harrop, SJ ;
Habash, J ;
Raftery, J ;
Kalb, J ;
Yariv, J ;
Hillier, IH ;
Helliwell, JR .
JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS, 1998, 94 (11) :1603-1611
[8]   Crystal structure of a dimeric mannose-specific agglutinin from garlic: Quaternary association and carbohydrate specificity [J].
Chandra, NR ;
Ramachandraiah, G ;
Bachhawat, K ;
Dam, TK ;
Surolia, A ;
Vijayan, M .
JOURNAL OF MOLECULAR BIOLOGY, 1999, 285 (03) :1157-1168
[9]   Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation [J].
Chen, J ;
Lee, KH ;
Steinhauer, DA ;
Stevens, DJ ;
Skehel, JJ ;
Wiley, DC .
CELL, 1998, 95 (03) :409-417
[10]   ANALYSIS OF HYDROPHOBICITY IN THE ALPHA-CHEMOKINE AND BETA-CHEMOKINE FAMILIES AND ITS RELEVANCE TO DIMERIZATION [J].
COVELL, DG ;
SMYTHERS, GW ;
GRONENBORN, AM ;
CLORE, GM .
PROTEIN SCIENCE, 1994, 3 (11) :2064-2072