Zinc phthalocyanine/magnetic fluid complex: A promising dual nanostructured system for cancer treatment

被引：37
作者：
Oliveira, Daniela M.
Lacava, Zulmira G. M.
Lima, Emilia C. D.
Morais, Paulo C.
Tedesco, Antonio C. [1 ]
机构：
[1] Univ Sao Paulo, FFCLRP USP, BR-14040901 Ribeirao Preto, SP, Brazil
[2] Univ Brasilia, Inst Ciencias Biol, BR-70910900 Brasilia, DF, Brazil
[3] Univ Fed Goias, Inst Quim, BR-74001970 Goiania, Go, Brazil
[4] Univ Brasilia, Inst Fis Nucl Fis Aplicada, BR-70919970 Brasilia, DF, Brazil
来源：
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2006年 / 6卷 / 08期
关键词：
nanobiotechnology; photodynamic therapy; hyperthermia; zinc phthalocyanine; magnetic fluid;
D O I：
10.1166/jnn.2006.512
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study we evaluated the photophysical, photochemical properties of the zinc phthalocyanine/ magnetic fluid (ZnPC/MF) complex in liposomal medium. As a result of the present investigation we propose the liposome-encapsulated ZnPC/MF complex as a very promising nanostructured device for cancer treatment. The spectroscopy characterization and the in vitro dark toxicity of both ZnPC and ZnPC/MF complex in Hank's and in liposomal medium are reported. Our findings revealed that the spectroscopic properties of the ZnPC associated or not with MF presented little differences and are very close to what one expects from an ideal photosensitizer compound. Indeed, the ZnPC/MF complex in liposomal medium presented lower dark toxicity compared to the ZnPC/MF complex in Hank's, strongly supporting the use of the former for cancer treatment.
引用
收藏
页码：2432 / 2437
页数：6
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