The Role of Inflammation in Lower Urinary Tract Symptoms (LUTS) due to Benign Prostatic Hyperplasia (BPH) and Its Potential Impact on Medical Therapy

被引：87
作者：
Ficarra, Vincenzo [1 ]
Rossanese, Marta [2 ]
Zazzara, Michele [2 ]
Giannarini, Gianluca [1 ]
Abbinante, Maria [1 ]
Bartoletti, Riccardo [3 ]
Mirone, Vincenzo [4 ]
Scaglione, Francesco [5 ]
机构：
[1] Univ Udine, Acad Med Ctr Hosp, Dept Expt & Clin Med Sci, Urol Unit, I-33100 Udine, Italy
[2] Univ Padua, Dept Surg Oncol & Gastrointestinal Sci, Urol Unit, Padua, Italy
[3] Univ Florence, Dept Urol, Florence, Italy
[4] Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy
[5] Univ Naples Federico II, Dept Urol, Naples, Italy
来源：
CURRENT UROLOGY REPORTS | 2014年 / 15卷 / 12期
关键词：
Inflammation; Lower urinary tract symptoms; Benign prostatic hyperplasia; Medical therapy; EXPRESSION;
D O I：
10.1007/s11934-014-0463-9
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A chronic prostatic inflammation seems to play a crucial role in benign prostatic hyperplasia (BPH) pathogenesis and progression. Therefore, inflammation could represent a new potential target for medical therapy of lower urinary tract symptoms (LUTS) due to BPH (LUTS/BPH). This review article analyzes the evidence supporting the role of inflammation in the onset and progression of BPH, and it assesses the potential impact of previous mechanisms on medical therapy of LUTS/BPH. Literature data support the role of inflammation as a relevant factor in the pathogenesis of BPH. Indeed, several data favour the role of infiltrating lymphocytes in the development and progression of prostate adenoma as an effect of a self-maintaining remodeling process. Although available drugs commonly used in the treatment of LUTS/BPH do not exhibit an anti-inflammatory activity, it seems to be obvious considering the inflammation as a new target in the treatment of LUTS/BPH. Drugs currently investigated for the treatment of prostatic inflammation include the hexanic lipidosterolic extract of Serenoa repens, nonsteroidal anti-inflammatory drugs, and vitamin D receptor agonists.
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