Near-infrared fluorescent probe for selective detection of Cu2+ in living cells and in Vivo

被引：16

作者：

Xu, Zhiyang ^{[1
]}

Wang, Hong ^{[1
]}

Chen, Zhen ^{[1
]}

Jiang, Hongli ^{[1
]}

Ge, Yanqing ^{[1
]}

机构：

[1] Taishan Med Univ, Sch Chem & Pharmaceut Engn, Tai An 271016, Shandong, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2019年 / 216卷

关键词：

NIR; Bioimaging; Fluorescent probe; Cu2+; NANOMOLAR DETECTION; COPPER; CHEMOSENSOR; SENSOR; CHEMODOSIMETER; CU(II); NIR;

D O I：

10.1016/j.saa.2019.03.062

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

A NIR-rhodamine fluorescent probe was designed and successfully synthesized. The structure of the probe NRh-Cu was characterized by H-1 NMR, C-13 NMR and HRMS. The probe was found to show high sensitivity and high selectivity. The detection limit was calculated to be as low as 0.95 ppb. The sensing mechanism was proposed and confirmed by HRMS spectra. Furthermore, it could be used for imaging Cu2+ in living cells and in vivo. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：404 / 410

页数：7

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