Oligomeric building block approach to the synthesis of diastereomerically pure pentathymidine 3′,5′-methanephosphonates

被引：6

作者：

Pyzowski, J ^{[1
]}

Wozniak, LA ^{[1
]}

Stec, WJ ^{[1
]}

机构：

[1] Polish Acad Sci, Ctr Mol & Macromol Studies, PL-90363 Lodz, Poland

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 06期

关键词：

D O I：

10.1021/ol991376o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for a large-scale synthesis of stereodefined oligo(nucleoside 3',5'-methanephosphonates) has been developed, based on transient 3'-O protection, which allows for the conversion of the protecting chirally defined methanephosphonanilidate group, located at the 3' end of a stereoregular oligomer, into diastereomerically pure "oligomeric building blocks" for stereospecific coupling with the 5'-OH group of another oligonucleotide.

引用

页码：771 / 773

页数：3

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