Phosphate Ester Hydrolysis: Metal Complexes As Purple Acid Phosphatase and Phosphotriesterase Analogues

被引：103

作者：

Gahan, Lawrence R. ^{[1
]}

Smith, Sarah J. ^{[1
]}

Neves, Ademir ^{[2
]}

Schenk, Gerhard ^{[1
]}

机构：

[1] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia

[2] Univ Fed Santa Catarina, Dept Quim, Lab Bioinorgan & Cristalog, BR-88040900 Florianopolis, SC, Brazil

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2009年 / 19期

基金：

澳大利亚研究理事会;

关键词：

Metalloenzymes; Biomimetics; Phosphoesterases; Iron; Zinc; BINUCLEAR IRON(III) COMPLEX; IRON OXO PROTEINS; UNSYMMETRICAL DINUCLEATING LIGAND; ASYMMETRIC DIIRON COMPLEXES; MONONUCLEAR ZN(II) COMPLEX; RAY CRYSTAL-STRUCTURES; FE-MN CENTER; ACTIVE-SITE; COPPER(II) COMPLEXES; MIXED-VALENCE;

D O I：

10.1002/ejic.200900231

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This microreview describes the structures and properties of a number of bimetallic complexes designed as both structural and functional mimics of the active sites of some specific metallohydrolase enzymes. The metalloenzymes in question include the predominantly monoesterase-activity-displaying purple acid phosphatase (PAP) and di- and triesterase enzymes, which have significant roles in the bioremedial hydrolysis of organophosphate pesticides and nerve gases. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

引用

页码：2745 / 2758

页数：14

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