Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines

被引：50
|
作者：
Chen, Mu-Wang [1 ]
Cai, Xian-Feng [1 ]
Chen, Zhang-Pei [1 ]
Shi, Lei [1 ]
Zhou, Yong-Gui [1 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 83期
基金：
中国国家自然科学基金;
关键词：
IRIDIUM-CATALYZED HYDROGENATION; ORGANOCATALYTIC TRANSFER HYDROGENATION; HIGHLY ENANTIOSELECTIVE HYDROGENATION; BRONSTED ACID; HETEROAROMATIC-COMPOUNDS; HANTZSCH ESTERS; DIASTEREOSELECTIVE SYNTHESIS; SECONDARY ALCOHOLS; AMINO-ALCOHOLS; EFFICIENT;
D O I：
10.1039/c4cc06060a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient and facile route to chiral tetrahydroquinolines with three contiguous stereogenic centers via a dynamic kinetic resolution process has been successfully developed by using chiral phosphoric acid as catalyst and Hantzsch ester as the hydrogen source with up to 89% ee.
引用
收藏
页码：12526 / 12529
页数：4
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