Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines

被引：52

作者：

Chen, Mu-Wang ^{[1
]}

Cai, Xian-Feng ^{[1
]}

Chen, Zhang-Pei ^{[1
]}

Shi, Lei ^{[1
]}

Zhou, Yong-Gui ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 83期

基金：

中国国家自然科学基金;

关键词：

IRIDIUM-CATALYZED HYDROGENATION; ORGANOCATALYTIC TRANSFER HYDROGENATION; HIGHLY ENANTIOSELECTIVE HYDROGENATION; BRONSTED ACID; HETEROAROMATIC-COMPOUNDS; HANTZSCH ESTERS; DIASTEREOSELECTIVE SYNTHESIS; SECONDARY ALCOHOLS; AMINO-ALCOHOLS; EFFICIENT;

D O I：

10.1039/c4cc06060a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and facile route to chiral tetrahydroquinolines with three contiguous stereogenic centers via a dynamic kinetic resolution process has been successfully developed by using chiral phosphoric acid as catalyst and Hantzsch ester as the hydrogen source with up to 89% ee.

引用

页码：12526 / 12529

页数：4

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