New furanoflavanoids, intestinal α-glucosidase inhibitory and free-radical (DPPH) scavenging, activity from antihyperglycemic root extract of Derris indica (Lam.)

被引：54

作者：

Rao, R. Ranga ^{[1
]}

Tiwari, Ashok K. ^{[2
]}

Reddy, P. Prabhakar ^{[1
]}

Babu, K. Suresh ^{[1
]}

Ali, Amtul Z. ^{[2
]}

Madhusudana, K. ^{[2
]}

Rao, J. Madhusudana ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Nat Prod Lab, Hyderabad 500607, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Div Pharmacol, Hyderabad 500607, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 14期

关键词：

Derris indica; Leguminosae; Furanoflavonoids; alpha-Glucosidase inhibition; 1,1-Diphenyl-2-picrylhydrazyl radical scavenging; Starch tolerance test; Antihyperglycemic activity; DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE; PONGAMIA-GLABRA; CONSTITUENTS; PREVENTION; DIETARY;

D O I：

10.1016/j.bmc.2009.05.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A bioassay-guided fractionation and chemical examination of antihyperglycemic root extract of Derris indica resulted in isolation and characterization of two new furanoflavanoids (1, 2) along with thirteen known compounds (3-15). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. All the compounds were tested in vitro for intestinal alpha-glucosidase inhibitory and DPPH radical activity. New compounds (1, 2) displayed moderate intestinal alpha-glucosidase inhibitory as well as free radical scavenging activity. Other compounds also displayed varying degrees of moderate intestinal alpha-glucosidase inhibitory activity. Pongamol (6) displayed potent intestinal alpha-glucosidase inhibition. (C) 2009 Published by Elsevier Ltd.

引用

页码：5170 / 5175

页数：6

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