The CRISPR Growth Spurt: from Bench to Clinic on Versatile Small RNAs

被引：17

作者：

Bayat, Hadi ^{[1
,2
]}

Omidi, Meysam ^{[1
,2
]}

Rajabibazl, Masoumeh ^{[3
]}

Sabri, Suriana ^{[4
]}

Rahimpour, Azam ^{[1
,2
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Med Nano Technol Tissue Engn Res Ctr, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Regenerat Med, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Sch Med, Dept Clin Biochem, Tehran, Iran

[4] Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Dept Microbiol, Serdang 43400, Malaysia

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2017年 / 27卷 / 02期

关键词：

CRISPR-Cas system; DNA repair; adoptive immunity; genome editing; IN-VIVO; GUIDED ENDONUCLEASE; TARGET CLEAVAGE; DNA CLEAVAGE; GENOME; CAS9; GENERATION; NUCLEASES; SYSTEM; COMPLEX;

D O I：

10.4014/jmb.1607.07005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Clustered regulatory interspaced short palindromic repeats (CRISPR) in association with CRISPR-associated protein (Cas) is an adaptive immune system, playing a pivotal role in the defense of bacteria and archaea. Ease of handling and cost effectiveness make the CRISPR-Cas system an ideal programmable nuclease tool. Recent advances in understanding the CRISPR-Cas system have tremendously improved its efficiency. For instance, it is possible to recapitulate the chronicle CRISPR-Cas from its infancy and inaugurate a developed version by generating novel variants of Cas proteins, subduing off-target effects, and optimizing of innovative strategies. In summary, the CRISPR-Cas system could be employed in a number of applications, including providing model systems, rectification of detrimental mutations, and antiviral therapies.

引用

页码：207 / 218

页数：12

共 96 条

[1] C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector [J].

Abudayyeh, Omar O. ;

Gootenberg, Jonathan S. ;

Konermann, Silvana ;

Joung, Julia ;

Slaymaker, Ian M. ;

Cox, David B. T. ;

Shmakov, Sergey ;

Makarova, Kira S. ;

Semenova, Ekaterina ;

Minakhin, Leonid ;

Severinov, Konstantin ;

Regev, Aviv ;

Lander, Eric S. ;

Koonin, Eugene V. ;

Zhang, Feng .

SCIENCE, 2016, 353 (6299)

[2] Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease [J].

Anders, Carolin ;

Niewoehner, Ole ;

Duerst, Alessia ;

Jinek, Martin .

NATURE, 2014, 513 (7519) :569-+

[3] A prudent path forward for genomic engineering and germline gene modification [J].

Baltimore, David ;

Berg, Paul ;

Botchan, Michael ;

Carroll, Dana ;

Charo, R. Alta ;

Church, George ;

Corn, Jacob E. ;

Daley, George Q. ;

Doudna, Jennifer A. ;

Fenner, Marsha ;

Greely, Henry T. ;

Jinek, Martin ;

Martin, G. Steven ;

Penhoet, Edward ;

Puck, Jennifer ;

Sternberg, Samuel H. ;

Weissman, Jonathan S. ;

Yamamoto, Keith R. .

SCIENCE, 2015, 348 (6230) :36-38

[4] UTILITY OF THE MULTIVARIATE APPROACH IN PREDICTING β-THALASSEMIA INTERMEDIA OR β-THALASSEMIA MAJOR TYPES IN IRANIAN PATIENTS [J].

Banan, Mehdi ;

Bayat, Hadi ;

Namdar-Aligoodarzi, Pegah ;

Azarkeivan, Azita ;

Kamali, Koorosh ;

Daneshmand, Parvaneh ;

Zaker-Kandjani, Behzad ;

Najmabadi, Hossein .

HEMOGLOBIN, 2013, 37 (05) :413-422

[5] THE XmnI AND BCL11A SINGLE NUCLEOTIDE POLYMORPHISMS MAY HELP PREDICT HYDROXYUREA RESPONSE IN IRANIAN β-THALASSEMIA PATIENTS [J].

Banan, Mehdi ;

Bayat, Hadi ;

Azarkeivan, Azita ;

Mohammadparast, Saeid ;

Kamali, Koorosh ;

Farashi, Samaneh ;

Bayat, Nooshin ;

Khani, Masumeh Hadavand ;

Neishabury, Maryam ;

Najmabadi, Hossein .

HEMOGLOBIN, 2012, 36 (04) :371-380

[6] An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level [J].

Bauer, Daniel E. ;

Kamran, Sophia C. ;

Lessard, Samuel ;

Xu, Jian ;

Fujiwara, Yuko ;

Lin, Carrie ;

Shao, Zhen ;

Canver, Matthew C. ;

Smith, Elenoe C. ;

Pinello, Luca ;

Sabo, Peter J. ;

Vierstra, Jeff ;

Voit, Richard A. ;

Yuan, Guo-Cheng ;

Porteus, Matthew H. ;

Stamatoyannopoulos, John A. ;

Lettre, Guillaume ;

Orkin, Stuart H. .

SCIENCE, 2013, 342 (6155) :253-257

[7] Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells [J].

Black, Joshua B. ;

Adler, Andrew F. ;

Wang, Hong-Gang ;

D'Ippolito, Anthony M. ;

Hutchinson, Hunter A. ;

Reddy, Timothy E. ;

Pitt, Geoffrey S. ;

Leong, Kam W. ;

Gersbach, Charles A. .

CELL STEM CELL, 2016, 19 (03) :406-414

[8] DNA-binding-domain fusions enhance the targeting range and precision of Cas9 [J].

Bolukbasi, Mehmet Fatih ;

Gupta, Ankit ;

Oikemus, Sarah ;

Derr, Alan G. ;

Garber, Manuel ;

Brodsky, Michael H. ;

Zhu, Lihua Julie ;

Wolfe, Scot A. .

NATURE METHODS, 2015, 12 (12) :1150-+

[9] The potential impact of new generation transgenic methods on creating rabbit models of cardiac diseases [J].

Bosze, Z. ;

Major, P. ;

Baczko, I. ;

Odening, K. E. ;

Bodrogi, L. ;

Hiripi, L. ;

Varro, A. .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2016, 121 (02) :123-130

[10] Genome Engineering with Targetable Nucleases [J].

Carroll, Dana .

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83, 2014, 83 :409-439

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