The CRISPR Growth Spurt: from Bench to Clinic on Versatile Small RNAs

被引：17
作者：
Bayat, Hadi [1 ,2 ]
Omidi, Meysam [1 ,2 ]
Rajabibazl, Masoumeh [3 ]
Sabri, Suriana [4 ]
Rahimpour, Azam [1 ,2 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Med Nano Technol Tissue Engn Res Ctr, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Regenerat Med, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Sch Med, Dept Clin Biochem, Tehran, Iran
[4] Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Dept Microbiol, Serdang 43400, Malaysia
来源：
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2017年 / 27卷 / 02期
关键词：
CRISPR-Cas system; DNA repair; adoptive immunity; genome editing; IN-VIVO; GUIDED ENDONUCLEASE; TARGET CLEAVAGE; DNA CLEAVAGE; GENOME; CAS9; GENERATION; NUCLEASES; SYSTEM; COMPLEX;
D O I：
10.4014/jmb.1607.07005
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Clustered regulatory interspaced short palindromic repeats (CRISPR) in association with CRISPR-associated protein (Cas) is an adaptive immune system, playing a pivotal role in the defense of bacteria and archaea. Ease of handling and cost effectiveness make the CRISPR-Cas system an ideal programmable nuclease tool. Recent advances in understanding the CRISPR-Cas system have tremendously improved its efficiency. For instance, it is possible to recapitulate the chronicle CRISPR-Cas from its infancy and inaugurate a developed version by generating novel variants of Cas proteins, subduing off-target effects, and optimizing of innovative strategies. In summary, the CRISPR-Cas system could be employed in a number of applications, including providing model systems, rectification of detrimental mutations, and antiviral therapies.
引用
收藏
页码：207 / 218
页数：12
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