The total synthesis of (+)-tedanolide

被引：50

作者：

Ehrlich, Gunnar ^{[1
]}

Hassfeld, Jorma ^{[1
]}

Eggert, Ulrike ^{[1
]}

Kalesse, Markus ^{[1
]}

机构：

[1] Leibniz Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 43期

关键词：

D O I：

10.1021/ja0659572

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first total synthesis of the (+)-tedanolide is described. Pivotal steps are the Felkin-selective aldol coupling between C12 and C13 and an efficient Mitsunobu macrolactonization. Selective protecting group transformations and subsequent oxidations generate the macrocyclic triketone. In the endgame of the synthesis, four TBS groups are removed in one reaction and a chemo- and stereoselective final step epoxidation generates (+)-tedanolide. Copyright © 2006 American Chemical Society.

引用

页码：14038 / 14039

页数：2

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