Retinal regeneration mechanisms linked to multiple cancer molecules: A therapeutic conundrum

被引：8

作者：

Barber, Amanda ^{[1
]}

Farmer, Kyle ^{[2
]}

Martin, Keith R. ^{[1
,3
,4
]}

Smith, Patrice D. ^{[1
,2
]}

机构：

[1] Univ Cambridge, John van Geest Ctr Brain Repair, Cambridge, England

[2] Carleton Univ, Dept Neurosci, Ottawa, ON, Canada

[3] Wellcome Trust Cambridge Stem Cell Inst, Med Res Council, Cambridge, England

[4] Cambridge NIHR Biomed Res Ctr, Cambridge, England

来源：

PROGRESS IN RETINAL AND EYE RESEARCH | 2017年 / 56卷

基金：

英国医学研究理事会;

关键词：

Retinal ganglion cells; Axon regeneration; Cancer genes; PTEN; Visual system repair mechanisms; CENTRAL-NERVOUS-SYSTEM; CNS AXON REGENERATION; COLONY-STIMULATING FACTORS; GROWTH-FACTOR RECEPTOR; TUMOR-SUPPRESSOR PTEN; RHO-ASSOCIATED KINASE; SPINAL-CORD-INJURY; CELL LUNG-CANCER; OPTIC-NERVE; GANGLION-CELLS;

D O I：

10.1016/j.preteyeres.2016.08.003

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Over the last decade, a large number of research articles have been published demonstrating regeneration and/or neuroprotection of retinal ganglion cells following manipulation of specific genetic and molecular targets. Interestingly, of the targets that have been identified to promote repair following visual system damage, many are genes known to be mutated in different types of cancer. This review explores recent literature on the potential for modulating cancer genes as a therapeutic strategy for visual system repair and looks at the potential clinical challenges associated with implementing this type of therapy. We also discuss signalling mechanisms that have been implicated in cancer and consider how similar mechanisms may improve axonal regeneration in the optic nerve. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：19 / 31

页数：13

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