Retinal regeneration mechanisms linked to multiple cancer molecules: A therapeutic conundrum

被引:8
作者
Barber, Amanda [1 ]
Farmer, Kyle [2 ]
Martin, Keith R. [1 ,3 ,4 ]
Smith, Patrice D. [1 ,2 ]
机构
[1] Univ Cambridge, John van Geest Ctr Brain Repair, Cambridge, England
[2] Carleton Univ, Dept Neurosci, Ottawa, ON, Canada
[3] Wellcome Trust Cambridge Stem Cell Inst, Med Res Council, Cambridge, England
[4] Cambridge NIHR Biomed Res Ctr, Cambridge, England
基金
英国医学研究理事会;
关键词
Retinal ganglion cells; Axon regeneration; Cancer genes; PTEN; Visual system repair mechanisms; CENTRAL-NERVOUS-SYSTEM; CNS AXON REGENERATION; COLONY-STIMULATING FACTORS; GROWTH-FACTOR RECEPTOR; TUMOR-SUPPRESSOR PTEN; RHO-ASSOCIATED KINASE; SPINAL-CORD-INJURY; CELL LUNG-CANCER; OPTIC-NERVE; GANGLION-CELLS;
D O I
10.1016/j.preteyeres.2016.08.003
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Over the last decade, a large number of research articles have been published demonstrating regeneration and/or neuroprotection of retinal ganglion cells following manipulation of specific genetic and molecular targets. Interestingly, of the targets that have been identified to promote repair following visual system damage, many are genes known to be mutated in different types of cancer. This review explores recent literature on the potential for modulating cancer genes as a therapeutic strategy for visual system repair and looks at the potential clinical challenges associated with implementing this type of therapy. We also discuss signalling mechanisms that have been implicated in cancer and consider how similar mechanisms may improve axonal regeneration in the optic nerve. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:19 / 31
页数:13
相关论文
共 138 条
[1]   Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves [J].
Abe, Namiko ;
Borson, Steven H. ;
Gambello, Michael J. ;
Wang, Fan ;
Cavalli, Valeria .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (36) :28034-28043
[2]   ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors [J].
Ahmed, Zubair ;
Berry, Martin ;
Logan, Ann .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2009, 42 (02) :128-133
[3]   Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity [J].
Anastassiadis, Theonie ;
Deacon, Sean W. ;
Devarajan, Karthik ;
Ma, Haiching ;
Peterson, Jeffrey R. .
NATURE BIOTECHNOLOGY, 2011, 29 (11) :1039-U117
[4]   Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors [J].
Apara, Akintomide ;
Goldberg, Jeffrey L. .
NEURAL REGENERATION RESEARCH, 2014, 9 (15) :1418-1421
[5]   Inhibition of Planar Cell Polarity Extends Neural Growth During Regeneration, Homeostasis, and Development [J].
Beane, Wendy S. ;
Tseng, Ai-Sun ;
Morokuma, Junji ;
Lemire, Joan M. ;
Levin, Michael .
STEM CELLS AND DEVELOPMENT, 2012, 21 (12) :2085-2094
[6]   RhoA/Rho-kinase activation promotes lung fibrosis in an animal model of systemic sclerosis [J].
Bei, Yihua ;
Thong Hua-Huy ;
Nicco, Carole ;
Sy Duong-Quy ;
Nhat-Nam Le-Dong ;
Kiet-Phong Tiev ;
Chereau, Christiane ;
Batteux, Frederic ;
Anh Tuan Dinh-Xuan .
EXPERIMENTAL LUNG RESEARCH, 2016, 42 (01) :44-55
[7]   Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics [J].
Belin, Stephane ;
Nawabi, Homaira ;
Wang, Chen ;
Tang, Shaojun ;
Latremoliere, Alban ;
Warren, Peter ;
Schorle, Hubert ;
Uncu, Ceren ;
Woolf, Clifford J. ;
He, Zhigang ;
Steen, Judith A. .
NEURON, 2015, 86 (04) :1000-1014
[8]  
Benowitz LI., 2015, EXP NEUROL, P30141
[9]   Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth [J].
Benson, MD ;
Romero, MI ;
Lush, ME ;
Lu, QR ;
Henkemeyer, M ;
Parada, LF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (30) :10694-10699
[10]   Epidermal growth factor receptor antagonists and CNS axon regeneration: Mechanisms and controversies [J].
Berry, Martin ;
Ahmed, Zubair ;
Douglas, Michael R. ;
Logan, Ann .
BRAIN RESEARCH BULLETIN, 2011, 84 (4-5) :289-299