Clinical Features and Outcomes of Primary Spinal Cord Glioblastoma: A Single-Center Experience and Literature Review

被引:10
作者
Yang, Kaiyuan [1 ,2 ]
Man, Weitao [1 ,2 ]
Jing, Linkai [1 ,2 ]
Sun, Zhenxing [1 ,2 ]
Liang, Ping [1 ,2 ]
Wang, James [1 ,2 ]
Wang, Guihuai [1 ,2 ]
机构
[1] Tsinghua Univ, Sch Clin Med, Beijing, Peoples R China
[2] Tsinghua Univ, Beijing Tsinghua Changgung Hosp, Sch Clin Med, Dept Neurosurg, Beijing, Peoples R China
关键词
Chemotherapy; Primary spinal cord glioblastoma; Prognosis; Radiotherapy; Surgery; HIGH-GRADE GLIOMAS; SURGICAL RESECTION; MULTIFORME; SURVIVAL; DISSEMINATION; MUTATIONS; PROGNOSIS; EXTENT;
D O I
10.1016/j.wneu.2020.07.066
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
OBJECTIVE: We aim to elucidate the clinical charac-teristics of patients with primary spinal cord glioblastoma (PSC GBM) and prognostic factors for their outcomes. METHODS: A cohort of 11 patients with pathologically diagnosed PSC GBM from our center were retrospectively reviewed. The clinical, radiologic, operative, and molecular information were recorded, and univariate analysis was performed to identify prognostic factors. RESULTS: The patient cohort included 5 males (45.5%) and 6 females (54.5%) with a median age of 26 years (range, 9-69 years). The median duration of the preoperative symptoms was 4.0 months (range, 0.5-120 months). Subtotal resection was achieved in 8 patients (72.7%) and partial resection in 3 (27.3%). Two patients (18.2%) underwent postoperative adjuvant chemoradiotherapy, 2 patients underwent (27.3%) chemotherapy only, and 6 patients (54.5%) neither. Two patients underwent additional therapy with bevacizumab. After a mean follow-up of 12.4 months (range, 1-33 months), Kaplan Meier plot showed that the median progression-free survival and overall survival were 6.0 (range, 0.5-12.0) months and 12.0 (range, 1.0-33.0) months, respectively, and 1-year survival was 31.8%. Age at diagnosis and duration of the preoperative symptoms were confirmed as prognostic factors of progression-free survival and overall survival in univariate analysis (P < 0.05). CONCLUSIONS: Despite aggressive treatment, PSC GBM still has a dismal prognosis and leads to severe neurologic deficit. Age at diagnosis and duration of the preoperative symptoms were confirmed as prognostic factors, yet the role of adjuvant radiochemotherapy and extent of resection are still unclear, necessitating further research.
引用
收藏
页码:E157 / E165
页数:9
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