Association of takotsubo cardiomyopathy and long QT syndrome

被引:42
作者
Sasaki, Osamu
Nishioka, Toshihiko
Akima, Takashi
Tabata, Hirotsugu
Okamoto, Yasuhiro
Akanuma, Masahiko
Uehata, Akimi
Takase, Bonpei
Katsushika, Shuichi
Isojima, Kazushige
Ohtomi, Shingo
Yoshimoto, Nobuo
机构
[1] Saitama Med Univ, Saitama Med Ctr, Div Cardiol, Kawagoe, Saitama 3508550, Japan
[2] Natl Def Med Coll, Dept Internal Med 1, Tokorozawa, Saitama 359, Japan
[3] Self Def Forces Cent Hosp, Dept Internal Med 1, Tokyo, Japan
[4] Mishuku Hosp, Div Cardiol, Tokyo, Japan
关键词
long QT syndrome; takotsubo cardiomyopathy; torsades de pointes;
D O I
10.1253/circj.70.1220
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A young woman presented with takotsubo cardiomyopathy after a syncopal attack caused by torsades de pointes. Two-dimensional echocardiography on admission showed left ventricular apical akinesis (ballooning) and basal hyperkinesis, compatible with takotsubo cardiomyopathy. This gradually normalized in 2 months. ECG on admission showed remarkable QT prolongation, U waves, and negative T waves, which also gradually normalized. Coronary angiography revealed no organic stenosis; however, acetylcholine provocation test caused the QT interval to again become prolonged. During treadmill exercise stress testing, the QT interval shortened as heart rate increased. Therefore, without genetic analysis, this patient was considered to have sporadic long QT syndrome in which takotsubo cardiomyopathy developed after the syncopal attack caused by torsades de pointes.
引用
收藏
页码:1220 / 1222
页数:3
相关论文
共 12 条
[1]  
AIZAWA Y, 1994, JPN HEART J, V35, P683
[2]   Acetylcholine-induced prolongation of the QT interval in idiopathic long QT syndrome [J].
Aizawa, Y ;
Washizuka, T ;
Igarashi, Y ;
Kitazawa, H ;
Chinushi, M ;
Abe, A ;
Shibata, A .
AMERICAN JOURNAL OF CARDIOLOGY, 1996, 77 (10) :879-&
[3]   Systematic review: Transient left ventricular apical ballooning: A syndrome that mimics ST-segment elevation myocardial infarction [J].
Bybee, KA ;
Kara, T ;
Prasad, A ;
Lerman, A ;
Barsness, GW ;
Wright, RS ;
Rihal, CS .
ANNALS OF INTERNAL MEDICINE, 2004, 141 (11) :858-865
[4]  
Dote K, 1991, J Cardiol, V21, P203
[5]   Effect of atropine on QT prolongation and torsade de pointes induced by intracoronary acetylcholine in the long QT syndrome [J].
Furushima, H ;
Niwano, S ;
Chinushi, M ;
Yamaura, M ;
Taneda, K ;
Washizuka, T ;
Aizawa, Y .
AMERICAN JOURNAL OF CARDIOLOGY, 1999, 83 (05) :714-718
[6]   Time course of electrocardiographic changes in patients with tako-tsubo syndrome - Comparison with acute myocardial infarction with minimal enzymatic release [J].
Kurisu, S ;
Inoue, I ;
Kawagoe, T ;
Ishihara, M ;
Shimatani, Y ;
Nakamura, S ;
Yoshida, M ;
Mitsuba, N ;
Hata, T ;
Sato, H .
CIRCULATION JOURNAL, 2004, 68 (01) :77-81
[7]   Human stress cardiomyopathy mimicking acute myocardial syndrome [J].
Pavin, D ;
LeBreton, H ;
Daubert, C .
HEART, 1997, 78 (05) :509-511
[8]   LONG QT SYNDROME PATIENTS WITH MUTATIONS OF THE SCN5A AND HERG GENES HAVE DIFFERENTIAL RESPONSES TO NA+ CHANNEL BLOCKADE AND TO INCREASES IN HEART-RATE - IMPLICATIONS FOR GENE-SPECIFIC THERAPY [J].
SCHWARTZ, PJ ;
PRIORI, SG ;
LOCATI, EH ;
NAPOLITANO, C ;
CANTU, F ;
TOWBIN, JA ;
KEATING, MT ;
HAMMOUDE, H ;
BROWN, AM ;
CHEN, LSK ;
COLATSKY, TJ .
CIRCULATION, 1995, 92 (12) :3381-3386
[9]   Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome -: Effects of β-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes [J].
Shimizu, W ;
Antzelevitch, C .
CIRCULATION, 1998, 98 (21) :2314-2322
[10]   Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome [J].
Shimizu, W ;
Antzelevitch, C .
CIRCULATION, 1997, 96 (06) :2038-2047