Progress and perspectives of neural tissue engineering

被引:45
作者
Gu, Xiaosong [1 ]
机构
[1] Nantong Univ, Coinnovat Ctr Neuroregenerat, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Peoples R China
基金
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词
nerve injury; tissue engineering; nerve grafts; PERIPHERAL-NERVE REGENERATION; ACHYRANTHES-BIDENTATA POLYPEPTIDES; SCHWANN-CELL PROLIFERATION; TRANSECTED SPINAL-CORD; EXTRACELLULAR-MATRIX; IN-VITRO; AXON REGENERATION; EMERGING ROLES; GROWTH-FACTOR; SILK FIBROIN;
D O I
10.1007/s11684-015-0415-x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Traumatic injuries to the nervous system lead to a common clinical problem with a quite high incidence and affect the patient's quality of life. Based on a major challenge not yet addressed by current therapeutic interventions for these diseases, a novel promising field of neural tissue engineering has emerged, grown, and attracted increasing interest. This review provides a brief summary of the recent progress in the field, especially in combination with the research experience of the author's group. Several important aspects related to tissue engineered nerves, including the theory on their construction, translation into the clinic, improvements in fabrication technologies, and the formation of a regenerative environment, are delineated and discussed. Furthermore, potential research directions for the future development of neural tissue engineering are suggested.
引用
收藏
页码:401 / 411
页数:11
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