A Facile Synthesis of 2-(Benzofuran-2-yI)-6-chloroquinoline3-carboxylic Acid Derivatives

被引：1
|
作者：
Gao, Wentao [1 ]
Fu, Xinbo [1 ]
Li, Yang [1 ]
Wang, Dongfang [1 ]
Zhao, Yanan [1 ]
机构：
[1] Bohai Univ, Inst Superfine Chem, Jinzhou 121000, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 36卷 / 12期
基金：
中国国家自然科学基金;
关键词：
ethyl 6-chloro-2-(chloromethyDquinoline-3-carboxylate; benzo(naphtho)furan; PEG-400; ultrasound-assisted; three-step one-pot; BIOLOGICAL EVALUATION; ANTICANCER AGENTS; HIGHLY EFFICIENT; QUINOLINE; ANTIBACTERIAL; TOXICITY; ACRIDINE; HYBRIDS; DESIGN;
D O I：
10.6023/cjoc201604058
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile synthesis of 2-(benzo(naphtho)furan-2-yl)-6-chloroquinoline-3-carboxylic acid derivatives (3a similar to p) has been described, involving ultrasound-assisted three-step one-pot reaction of ethyl 6-chloro-2-(chloromethyl)quinoline3-carboxylate (1) with corresponding salicylaldehydes (2a similar to 2i), 1-(2-hydroxyphenyl)ethanones (2j similar to 2o) or 2-hydroxy-1-naphthaldehyde (2p) in the presence of K2CO3 as acid-binding agent and PEG-400 as phase transfer catalyst in refluxing MeCN. The synthesized compounds were new, and their structures had been determined by IR, H-1 NMR, C-13 NMR and HRMS.
引用
收藏
页码：2965 / 2972
页数：8
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