Interleukin-1 system in the human fallopian tube-No spatial but a temporal regulation of mRNA and protein expression

被引：10

作者：

Hess, A. P. ^{[1
]}

Baston-Buest, D. M. ^{[1
]}

Schanz, A. ^{[1
]}

Hirchenhain, J. ^{[1
]}

Bielfeld, P. ^{[2
]}

Kruessel, J. S. ^{[1
]}

机构：

[1] Univ Dusseldorf, Med Ctr, Dept Gynecol & Obstet, D-40225 Dusseldorf, Germany

[2] Novum, Ctr Reprod Med, D-45127 Essen, Germany

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2009年 / 303卷 / 1-2期

关键词：

Interleukin-1 (IL-1) system; Human fallopian tube; Interleukin-1 receptor type I (IL-1R t1); Interleukin-1 receptor antagonist (IL-1ra); Implantation; Spatial and temporal expression pattern; RECEPTOR ANTAGONIST EXPRESSION; ENDOMETRIAL STROMAL CELLS; IL-1; RECEPTOR; I RECEPTOR; RIBONUCLEIC-ACID; MENSTRUAL-CYCLE; MICE LACKING; IMPLANTATION; TROPHOBLAST; PREGNANCY;

D O I：

10.1016/j.mce.2009.01.017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The human fallopian tube provides the environment for the first 5 days of embryonic development in vivo. The IL-1 system is involved in human embryo implantation. This study aimed to investigate IL-1 beta, IL-1ra and IL-1R tI expression within the length of the human fallopian tube on mRNA- and protein-level in samples from proliferative versus secretory phase, postmenopause (PMP) samples and samples from intra- (IUP) and extrauterine pregnancies (EUP) to examine possible spatial and hormonal induced changes (fimbrial, ampullary and isthmic tube segments). On mRNA-level, IL-1 beta was expressed in all samples except in PMP. IL-1R tI could be detected in all samples whereas IL-1ra was only expressed in secretory phase and the IUP sample. Immunohistochemically we could detect IL-1 beta and IL-1R t1 protein in all proliferative and secretory phase samples with maximum intensity in secretory phase samples whereas IL-1ra was expressed in secretory phase samples only. Overall no spatial but temporal differences possibly due to hormonal changes could be observed suggesting a precise regulation of the IL-1 system. especially for IL-1ra and moreover a stable molecular architecture within the full length of the fallopian tube. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：7 / 12

页数：6

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