Macropinocytosis Fuels Prostate Cancer

被引：12

作者：

Commisso, Cosimo ^{[1
]}

Debnath, Jayanta ^{[2
,3
]}

机构：

[1] Sanford Burnham Prebys Med Discovery Inst, Tumor Initiat & Maintenance Program, NCI Designated Canc Ctr, La Jolla, CA 92037 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA

[3] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

来源：

CANCER DISCOVERY | 2018年 / 8卷 / 07期

关键词：

EXTRACELLULAR PROTEIN; MTORC1; TUMORS; CELLS;

D O I：

10.1158/2159-8290.CD-18-0513

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Kim and colleagues identify necrotic debris as a macropinocytic cargo in PTEN-deficient prostate cancer cells, which is catabolized to generate the nutrients and biomass necessary to support tumor cell growth and metabolism in nutrient-limiting conditions. (c) 2018 AACR.

引用

页码：800 / 802

页数：3

共 10 条

[1] Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells [J].

Commisso, Cosimo ;

Davidson, Shawn M. ;

Soydaner-Azeloglu, Rengin G. ;

Parker, Seth J. ;

Kamphorst, Jurre J. ;

Hackett, Sean ;

Grabocka, Elda ;

Nofal, Michel ;

Drebin, Jeffrey A. ;

Thompson, Craig B. ;

Rabinowitz, Joshua D. ;

Metallo, Christian M. ;

Vander Heiden, Matthew G. ;

Bar-Sagi, Dafna .

NATURE, 2013, 497 (7451) :633-+

[2] Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors [J].

Davidson, Shawn M. ;

Jonas, Oliver ;

Keibler, Mark A. ;

Hou, Han Wei ;

Luengo, Alba ;

Mayers, Jared R. ;

Wyckoff, Jeffrey ;

Del Rosario, Amanda M. ;

Whitman, Matthew ;

Chin, Christopher R. ;

Condon, Kendall J. ;

Lammers, Alex ;

Kellersberger, Katherine A. ;

Stall, Brian K. ;

Stephanopoulos, Gregory ;

Bar-Sagi, Dafna ;

Han, Jongyoon ;

Rabinowitz, Joshua D. ;

Cima, Michael J. ;

Langer, Robert ;

Vander Heiden, Matthew G. .

NATURE MEDICINE, 2017, 23 (02) :235-241

[3] Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein [J].

Kamphorst, Jurre J. ;

Nofal, Michel ;

Commisso, Cosimo ;

Hackett, Sean R. ;

Lu, Wenyun ;

Grabocka, Elda ;

Vander Heiden, Matthew G. ;

Miller, George ;

Drebin, Jeffrey A. ;

Bar-Sagi, Dafna ;

Thompson, Craig B. ;

Rabinowitz, Joshua D. .

CANCER RESEARCH, 2015, 75 (03) :544-553

[4] PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells [J].

Kim, Seong M. ;

Nguyen, Tricia T. ;

Ravi, Archna ;

Kubiniok, Peter ;

Finicle, Brendan T. ;

Jayashankar, Vaishali ;

Malacrida, Leonel ;

Hou, Jue ;

Robertson, Jane ;

Gao, Dong ;

Chernoff, Jonathan ;

Digman, Michelle A. ;

Potma, Eric O. ;

Tromberg, Bruce J. ;

Thibault, Pierre ;

Edinger, Aimee L. .

CANCER DISCOVERY, 2018, 8 (07) :866-883

[5] Autophagy and Tumor Metabolism [J].

Kimmelman, Alec C. ;

White, Eileen .

CELL METABOLISM, 2017, 25 (05) :1037-1043

[6] Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes [J].

Nakase, Ikuhiko ;

Kobayashi, Nahoko Bailey ;

Takatani-Nakase, Tomoka ;

Yoshida, Tetsuhiko .

SCIENTIFIC REPORTS, 2015, 5

[7] Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions [J].

Olivares, Orianne ;

Mayers, Jared R. ;

Gouirand, Victoire ;

Torrence, Margaret E. ;

Gicquel, Tristan ;

Borge, Laurence ;

Lac, Sophie ;

Roques, Julie ;

Lavaut, Marie-Noelle ;

Berthezene, Patrice ;

Rubis, Marion ;

Secq, Veronique ;

Garcia, Stephane ;

Moutardier, Vincent ;

Lombardo, Dominique ;

Iovanna, Juan Lucio ;

Tomasini, Richard ;

Guillaumond, Fabienne ;

Vander Heiden, Matthew G. ;

Vasseur, Sophie .

NATURE COMMUNICATIONS, 2017, 8

[8] The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1 [J].

Palm, Wilhelm ;

Park, Youngkyu ;

Wright, Kevin ;

Pavlova, Natalya N. ;

Tuveson, David A. ;

Thompson, Craig B. .

CELL, 2015, 162 (02) :259-270

[9] Macropinocytosis: A Metabolic Adaptation to nutrient Stress in Cancer [J].

Recouvreux, Maria Victoria ;

Commisso, Cosimo .

FRONTIERS IN ENDOCRINOLOGY, 2017, 8

[10] Growth factor signaling to mTORC1 by amino acid-laden macropinosomes [J].

Yoshida, Sei ;

Pacitto, Regina ;

Yao, Yao ;

Inoki, Ken ;

Swanson, Joel A. .

JOURNAL OF CELL BIOLOGY, 2015, 211 (01) :159-172

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