BONE DENSITY AND ALENDRONATE EFFECTS IN DUCHENNE MUSCULAR DYSTROPHY PATIENTS

被引:31
作者
Houston, Caroline [1 ]
Mathews, Katherine [2 ]
Shibli-Rahhal, Amal [1 ]
机构
[1] Univ Iowa Hosp & Clin, Div Endocrinol, Iowa City, IA 52242 USA
[2] Univ Iowa Hosp & Clin, Dept Pediat, Div Neurol, Iowa City, IA 52242 USA
关键词
alendronate; bone; Duchenne Muscular Dystrophy; glucocorticoids; osteoporosis; CORTICOSTEROID TREATMENT; VERTEBRAL FRACTURES; CONTROLLED TRIAL; MINERAL DENSITY; DOUBLE-BLIND; BOYS; PREDNISONE; OSTEOPOROSIS; DEFLAZACORT; MUSCLE;
D O I
10.1002/mus.23948
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: Patients with DMD have low bone mineral density (BMD) and are at high risk for fractures. We examined changes in BMD and the effects of alendronate in DMD patients treated at our institution in the last decade. Methods: Retrospective cohort study of 39 DMD patients. Results: Patients had screening dual energy x-ray absorptiometry (DXA) at an average age of 12 years. The vast majority had low Z-scores at the total hip and lumbar spine. Patients treated with glucocorticoids had a significantly lower Z-score at the spine than those not treated with glucocorticoids. Z-scores at the hip trended down without alendronate (P = 0.07) and trended up with alendronate (P = 0.4). Conclusions: By age 12 years, most patients with DMD had low Z-scores. They may have benefitted from earlier screening. Z-score at the hip trended downward without alendronate and trended upward (stabilized) with alendronate, but these trends were not statistically significant. Muscle Nerve 49:506-511, 2014
引用
收藏
页码:506 / 511
页数:6
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