Lessons from Structural Genomics

被引：82
|
作者：
Terwilliger, Thomas C. [1 ]
Stuart, David [2 ]
Yokoyama, Shigeyuki [3 ]
机构：
[1] Los Alamos Natl Lab, Los Alamos, NM 87545 USA
[2] Univ Oxford, Div Struct Biol, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
[3] RIKEN, Syst Struct Biol Ctr, Yokohama, Kanagawa 2300045, Japan
来源：
ANNUAL REVIEW OF BIOPHYSICS | 2009年 / 38卷
关键词：
international cooperation; protein structure; X-ray crystallography; nuclear magnetic resonance; THERMOTOGA-MARITIMA; PROTEIN-PRODUCTION; CRYSTAL-STRUCTURE; DATA-COLLECTION; CRYSTALLIZATION; BIOINFORMATICS; STRATEGY; PROTOCOL; SYSTEM; IMPACT;
D O I：
10.1146/annurev.biophys.050708.133740
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A decade of structural genomics, the large-scale determination of protein structures, has generated a wealth of data and many important lessons for structural biology and for future large-scale projects. These lessons include a conformation that it is possible to construct large-scale facilities that can determine die structures of a hundred or more proteins per year, that these structures can be of high quality, and that these structures can have an important impact. Technology development has played a critical role in structural genomics, the difficulties at each step of determining a structure of a particular protein can be quantified, and validation of technologies is nearly as important as the technologies themselves. Finally, rapid deposition of data in public databases has increased the impact and usefulness of the data and international cooperation has advanced the field and improved data sharing.
引用
收藏
页码：371 / 383
页数：13
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