Epithalon inhibits tumor growth and expression of HER-2/neu oncogene in breast tumors in transgenic mice characterized by accelerated aging

被引：4

作者：

Anisimov, VN

Khavinsov, VK

Alimova, IN

Provintsiali, M

Manchini, R

Francheski, K

机构：

[1] Russian Acad Med Sci, St Petersburg Inst Bioregulat & Gerontol, NW Div, Moscow 109801, Russia

[2] Russian Minist Hlth, NN Petrov Inst Oncol, Dept Carcinogenesis & Oncogerontol, St Petersburg, Russia

[3] Italian Natl Res Ctr Aging, Ancona, Italy

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 133卷 / 02期

关键词：

transgenic mice; HER-2/neu; breast cancer; peptides; Epithalon; Vilon;

D O I：

10.1023/A:1015555023692

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Female transgenic FVB mice carrying breast cancer gene HER-2/neu were monthly injected with Vilon or Epithalon (1 mug subcutaneously for 5 consecutive days) starting from the 2nd month of life. Epithalon markedly inhibited neoplasm development: the maximum size of breast adenacarcinomas was 33% lower than in the control (p<0.05). The intensity of HER-2/neu mRNA expression in breast tumors of Epithalon-treated mice was 3.7 times lower than in control animals. These results indicate that Epithalon inhibited breast tumor development in transgenic mice, which is probably related to suppression of HER-2/neu expression.

引用

页码：167 / 170

页数：4

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