Synthesis of α-chloroamides in water

被引：53

作者：

Harte, Andrew J. ^{[1
]}

Gunnlaugsson, Thorfinnur ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Chem, Ctr Synth & Chem Biol, Dublin 2, Ireland

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 35期

关键词：

D O I：

10.1016/j.tetlet.2006.06.090

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction between chloroacetyl chloride and mono- or bis-aliphatic or aromatic amines in water under basic or neutral conditions gives rise to the formation of a variety of functionalized alpha-chloroamides. The resulting products were obtained as solids in moderate to good yields, upon precipitation and isolation by filtration. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：6321 / 6324

页数：4

共 33 条

[1] LANTHANIDE(III) TETRAAMIDE MACROCYCLIC COMPLEXES AS SYNTHETIC RIBONUCLEASES - STRUCTURE AND CATALYTIC PROPERTIES OF [LA(TCMC)(CF3SO3)(ETOH)](CF3SO3)(2)
AMIN, S
MORROW, JR
LAKE, CH
CHURCHILL, MR
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1994, 33 (07): : 773 - 775
[2] Synthesis and phosphodiester transesterification activity of the La3+-complex of a novel functionalized octadentate ligand
Baykal, U
Akkaya, EU
[J]. TETRAHEDRON LETTERS, 1998, 39 (32) : 5861 - 5864
[3] PEG-supported pyridylthioesters for racemization-free amide synthesis: a reagent that allows simultaneous product formation and removal from the polymer
Benaglia, M
Guizzetti, S
Rigamonti, C
Puglisi, A
[J]. TETRAHEDRON, 2005, 61 (51) : 12100 - 12106
[4] Chemoselective amide ligations by decarboxylative condensations of N-alkylhydroxylamines and α-ketoacids
Bode, JW
Fox, RM
Baucom, KD
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (08) : 1248 - 1252
[5] Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications
Caravan, P
Ellison, JJ
McMurry, TJ
Lauffer, RB
[J]. CHEMICAL REVIEWS, 1999, 99 (09) : 2293 - 2352
[6] Iterative, aqueous synthesis of β3-oligopeptides without coupling reagents
Carrillo, N
Davalos, EA
Russak, JA
Bode, JW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (05) : 1452 - 1453
[7] Effect of mixed pendent groups on the solution and catalytic properties of europium(III) macrocyclic complexes: Bifunctional and monofunctional amide and alcohol pendents in septadentate or octadentate ligands
Chappell, LL
Voss, DA
Horrocks, WD
Morrow, JR
[J]. INORGANIC CHEMISTRY, 1998, 37 (16) : 3989 - 3998
[8] Copper-catalyzed hydrative amide synthesis with terminal alkyne, sulfonyl azide, and water
Cho, SH
Yoo, EJ
Bae, L
Chang, S
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (46) : 16046 - 16047
[9] Clayden J., 2001, ORGANIC CHEM
[10] Synthesis of aliphatic (E)-α,β-unsaturated amides with high diastereoselectivity from α,β-epoxyamides promoted by SmI2/HMPA
Concellón, JM
Bardales, E
[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2004, 2004 (07) : 1523 - 1526

← 1 2 3 4 →