Seroepidemiology of respiratory syncytial virus in western India with special reference to appropriate age for infant vaccination

被引：8

作者：

Arankalle, Vidya A. ^{[1
]}

Kulkarni, Ruta ^{[1
]}

Malshe, Nandini ^{[2
]}

Palkar, Sonali ^{[2
]}

Lalwani, Sanjay ^{[2
]}

Mishra, Akhilesh Chandra ^{[1
]}

机构：

[1] Bharati Vidyapeeth Deemed Be Univ, Dept Communicable Dis, IRSHA, Pune Satara Rd, Pune 411043, Maharashtra, India

[2] Bharati Vidyapeeth Med Coll, Dept Pediat, Pune, Maharashtra, India

来源：

JOURNAL OF MEDICAL VIROLOGY | 2019年 / 91卷 / 08期

关键词：

antibody prevalence; maternal antibodies; preterm; full-term infants; respiratory syncytial virus; TRACT INFECTIONS; CHILDREN; HOSPITALIZATION; ETIOLOGY; BURDEN;

D O I：

10.1002/jmv.25489

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Respiratory syncytial virus (RSV) causes significant infant mortality worldwide and a vaccine may be available soon. This study determined age-stratified anti-RSV antibody positivity (enzyme-linked immunosorbent assay [ELISA]) at Pune, India (cord blood-85 years). Antibody positivity declined from 100% at birth to 71.3% (3 months), and 0.7% (6 months). A significant rise was noted at 15 months (16%), 16 to 24 months (64.5%) and 4 years (95.2%) with concomitant IgM-anti-RSV positivity indicative of recent infection. Antibody decline was higher in infants born preterm than full-term. Across subsequent age groups including the elderly, antibody positivity was similar and comparable, suggestive of repeated exposure to the virus. Early protection/vaccination is essential for the infant population.

引用

页码：1566 / 1570

页数：5

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