Clinical and Laboratory Characteristics of Kawasaki Disease in Iran: A Systematic Review and Meta-analysis

Background Kawasaki Disease (KD) is a common systemic vasculitis, which mostly develops in children under five years. Based on our knowledge no meta-analysis, studies have been conducted to evaluate the clinical and laboratory findings of KD in Iran. We aimed to evaluate these characteristics in Iranian children with KD. Materials and Methods: In this Systematic review, online databases, including Medline, Scopus, Web of Science, EMBASE, Medlib, SID, Magiran, and Irandoc were searched until February 2020. The keywords of KD and characteristics were combined and searched. Search, and extraction of papers were performed by two authors independently. The prevalence rates of all clinical and laboratory characteristics of KD and involvement of other organs were analyzed by the random effect model using the STATA software (version 11.0). Results: Twenty studies were included. In clinical findings among KD patients fever was 100%, change in oral cavity and lips was 82%, bilateral conjunctiva was 78%, rash was 74%, change in extremities was 62%, agitation was 53%, and cervical lymphadenopathy was 50%. In laboratory findings, ESR was 86%, CRP was 67%, leukocytosis was 62%, Hb<10 g/dl was 59%, thrombocytosis was 55%, SGOT elevated was 34%, sterile pyuria was 33%, albuminuria was 31%, and SGPT elevated was 30%. In involvement of other organ, desquamation was 57%, vomiting was 30%, arthritis was 28%, diarrhea was 24%, coronary complication was 17%, coronary aneurysm was 17%, arthralgia was 16%, cardiac involvement was 10%, aseptic meningitis was 6%, gallbladder hydrops was 5%, and BCG inoculation site was 3%. Conclusion The fever, erythrocyte sedimentation rate, and desquamation are the most prevalent clinical, laboratory, and involvement of other organ characteristics respectively.