Assessment of Antiviral Properties of Peramivir against H7N9 Avian Influenza Virus in an Experimental Mouse Model

被引：7

作者：

Farooqui, Amber ^{[1
,2
,3
,4
]}

Huang, Linxi ^{[5
]}

Wu, Suwu ^{[6
]}

Cai, Yingmu ^{[7
]}

Su, Min ^{[8
]}

Lin, Pengzhou ^{[5
]}

Chen, Weihong ^{[6
]}

Fang, Xibin ^{[6
]}

Zhang, Li ^{[1
,2
]}

Liu, Yisu ^{[1
,2
]}

Zeng, Tiansheng ^{[1
,2
]}

Paquette, Stephane G. ^{[3
,9
]}

Khan, Adnan ^{[1
,2
,4
]}

Kelvin, Alyson A. ^{[3
]}

Kelvin, David J. ^{[1
,2
,3
,4
,9
,10
]}

机构：

[1] Univ Hlth Network, Int Inst Infect & Immun, Div Immunol, Shantou, Peoples R China

[2] Shantou Univ, Coll Med, Shantou, Guangdong, Peoples R China

[3] Toronto Gen Hosp, Univ Hlth Network, Res Inst, Div Expt Therapeut, Toronto, ON, Canada

[4] Guangdong Prov Key Lab Infect Dis & Mol Immunopat, Shantou, Guangdong, Peoples R China

[5] Shantou Univ, Coll Med, Affiliated Hosp 1, Dept Infect Dis, Shantou, Guangdong, Peoples R China

[6] Shantou Cent Hosp, Intens Care Unit, Shantou, Peoples R China

[7] Shantou Univ, Coll Med, Affiliated Hosp 1, Dept Lab Med, Shantou, Guangdong, Peoples R China

[8] Shantou Univ, Coll Med, Dept Pathol, Shantou, Guangdong, Peoples R China

[9] Univ Toronto, Fac Med, Inst Med Sci, Toronto, ON, Canada

[10] Univ Toronto, Fac Med, Dept Immunol, Toronto, ON, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 12期

关键词：

HUMAN INFECTION; A(H7N9) VIRUS; INTRAVENOUS PERAMIVIR; OSELTAMIVIR; MICE; TRANSMISSION; FERRETS; CHINA; H1N1; NEUROVIRULENCE;

D O I：

10.1128/AAC.01885-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The H7N9 influenza virus causes a severe form of disease in humans. Neuraminidase inhibitors, including oral oseltamivir and injectable peramivir, are the first choices of antiviral treatment for such cases; however, the clinical efficacy of these drugs is questionable. Animal experimental models are essential for understanding the viral replication kinetics under the selective pressure of antiviral agents. This study demonstrates the antiviral activity of peramivir in a mouse model of H7N9 avian influenza virus infection. The data show that repeated administration of peramivir at 30 mg/kg of body weight successfully eradicated the virus from the respiratory tract and extrapulmonary tissues during the acute response, prevented clinical signs of the disease, including neuropathy, and eventually protected mice against lethal H7N9 influenza virus infection. Early treatment with peramivir was found to be associated with better disease outcomes.

引用

页码：7255 / 7264

页数：10

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