The relationship between atopy and neurological manifestations in HTLV-1 infection

被引:1
作者
Lima Verde, Raquel Crisostomo [1 ,2 ]
Carneiro Neto, Jose Abraao [1 ]
Braga Santos, Silvane Maria [1 ,3 ,4 ]
Carvalho, Edgar Marcelino [1 ,4 ]
Lessa, Marcus Miranda [1 ,2 ]
机构
[1] Univ Fed Bahia, Hosp Univ Prof Edgard Santos, Dept Imunol, Salvador, BA, Brazil
[2] Univ Fed Bahia, Hosp Univ Prof Edgard Santos, Dept Otorrinolaringol, Salvador, BA, Brazil
[3] Univ Estadual Feira De Santana, Dept Ciencias Biol, Feira De Santana, BA, Brazil
[4] CNPq, INCT DT, Salvador, BA, Brazil
关键词
HTLV-1; Atopy; Allergy; Immunology; Cytokines; HAM/TSP; MYELOPATHY/TROPICAL SPASTIC PARAPARESIS; ASYMPTOMATIC CARRIERS; PROVIRAL LOAD; BLOOD-DONORS; HAM/TSP; IMMUNOMODULATION; INDIVIDUALS; ASTHMA;
D O I
10.1590/0037-8682-0162-2017
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1)induces exaggerated Th1 responses, whereas atopy is associated with exacerbated Th2 responses. Methods: Here, a cross-sectional study compared the prevalence of atopy in HTLV-1 carriers and HAM/TSP patients. It also compared the spontaneous cytokine production in HTLV-1-infected individuals. A retrospective cohort study evaluated the development of neurological manifestations in atopic and non-atopic carriers. Results: Atopic HAM/TSP patients with high IFN-gamma production exhibited higher IL-5 levels than non-atopic patients. Allergic rhinitis accelerated the development of Babinski signals and overactive bladders. Conclusions: Abnormal Th1 and Th2 responses coexist in HTLV-1-infected individuals and allergic diseases may worsen the clinical course of HTLV-1 infections.
引用
收藏
页码:207 / 211
页数:5
相关论文
共 50 条
[31]   Current State of Therapeutics for HTLV-1 [J].
Wang, Tiana T. ;
Hirons, Ashley ;
Doerflinger, Marcel ;
Morris, Kevin V. ;
Ledger, Scott ;
Purcell, Damian F. J. ;
Kelleher, Anthony D. ;
Ahlenstiel, Chantelle L. .
VIRUSES-BASEL, 2024, 16 (10)
[32]   HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice [J].
Ginwala, Rashida ;
Caruso, Breanna ;
Khan, Zafar K. ;
Pattekar, Ajinkya ;
Chew, Glen M. ;
Corley, Michael J. ;
Loonawat, Ronak ;
Jacobson, Steven ;
Sreedhar, Sreesha ;
Ndhlovu, Lishomwa C. ;
Jain, Pooja .
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2017, 12 (03) :504-520
[33]   Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load [J].
Vargens, Cristina Castro-Lima ;
Rios Grassi, Maria Fernanda ;
Boa-Sorte, Ney ;
Rathsam-Pinheiro, Regina Helena ;
Olavarria, Viviana Nilla ;
Kruschewsky, Ramon de Almeida ;
Galvao-Castro, Bernardo .
JOURNAL OF CLINICAL VIROLOGY, 2011, 52 (03) :177-180
[34]   Planning and management to control and eliminate HTLV-1 infection in Iran [J].
Boostani, Reza ;
Lotfinejad, Nasim ;
Zemorshidi, Fariba ;
Vahidi, Zohreh ;
Rezaee, Seyed Abdolrahim ;
Farid, Reza ;
Rafatpanah, Houshang .
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021, 24 (03) :264-266
[35]   HTLV-1 infection: what determines the risk of inflammatory disease? [J].
Tattermusch, Sonja ;
Bangham, Charles R. M. .
TRENDS IN MICROBIOLOGY, 2012, 20 (10) :494-500
[36]   Neurologic, clinical, and immunologic features in a cohort of HTLV-1 carriers with high proviral loads [J].
Ferraz, Sheila N. ;
Costa, Gabriela F. ;
Carneiro Neto, Jose Abraao ;
Hebert, Thiago ;
de Oliveira, Cassius J., V ;
Guerra, Mariele ;
Oliveira, Livia M. A. ;
Carvalho, Edgar M. .
JOURNAL OF NEUROVIROLOGY, 2020, 26 (04) :520-529
[37]   Role of microRNAs in HTLV-1 infection and transformation [J].
Ruggero, Katia ;
Corradin, Alberto ;
Zanovello, Paola ;
Amadori, Alberto ;
Bronte, Vincenzo ;
Ciminale, Vincenzo ;
D'Agostino, Donna M. .
MOLECULAR ASPECTS OF MEDICINE, 2010, 31 (05) :367-382
[38]   HTLV-1 Associated Neurological Complex. What is Hidden below the Water? [J].
Araujo, Abelardo Q. C. ;
Wedemann, Diego .
AIDS REVIEWS, 2019, 21 (04) :211-217
[39]   AUTOIMMUNE-DISEASE AND HTLV-1 INFECTION [J].
BOWNESS, P ;
DAVIES, KAA ;
TOSSWILL, J ;
BUNN, CC ;
MACALPINE, L ;
WEBER, JN ;
WALPORT, MJ .
BRITISH JOURNAL OF RHEUMATOLOGY, 1991, 30 (02) :141-143
[40]   HTLV-1 persistent infection and ATLL oncogenesis [J].
Zuo, Xiaorui ;
Zhou, Ruoning ;
Yang, Sikai ;
Ma, Guangyong .
JOURNAL OF MEDICAL VIROLOGY, 2023, 95 (01)