The relationship between atopy and neurological manifestations in HTLV-1 infection

被引：1
作者：
Lima Verde, Raquel Crisostomo [1 ,2 ]
Carneiro Neto, Jose Abraao [1 ]
Braga Santos, Silvane Maria [1 ,3 ,4 ]
Carvalho, Edgar Marcelino [1 ,4 ]
Lessa, Marcus Miranda [1 ,2 ]
机构：
[1] Univ Fed Bahia, Hosp Univ Prof Edgard Santos, Dept Imunol, Salvador, BA, Brazil
[2] Univ Fed Bahia, Hosp Univ Prof Edgard Santos, Dept Otorrinolaringol, Salvador, BA, Brazil
[3] Univ Estadual Feira De Santana, Dept Ciencias Biol, Feira De Santana, BA, Brazil
[4] CNPq, INCT DT, Salvador, BA, Brazil
来源：
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2018年 / 51卷 / 02期
关键词：
HTLV-1; Atopy; Allergy; Immunology; Cytokines; HAM/TSP; MYELOPATHY/TROPICAL SPASTIC PARAPARESIS; ASYMPTOMATIC CARRIERS; PROVIRAL LOAD; BLOOD-DONORS; HAM/TSP; IMMUNOMODULATION; INDIVIDUALS; ASTHMA;
D O I：
10.1590/0037-8682-0162-2017
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1)induces exaggerated Th1 responses, whereas atopy is associated with exacerbated Th2 responses. Methods: Here, a cross-sectional study compared the prevalence of atopy in HTLV-1 carriers and HAM/TSP patients. It also compared the spontaneous cytokine production in HTLV-1-infected individuals. A retrospective cohort study evaluated the development of neurological manifestations in atopic and non-atopic carriers. Results: Atopic HAM/TSP patients with high IFN-gamma production exhibited higher IL-5 levels than non-atopic patients. Allergic rhinitis accelerated the development of Babinski signals and overactive bladders. Conclusions: Abnormal Th1 and Th2 responses coexist in HTLV-1-infected individuals and allergic diseases may worsen the clinical course of HTLV-1 infections.
引用
收藏
页码：207 / 211
页数：5
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