CXCR7 Is Highly Expressed in Acute Lymphoblastic Leukemia and Potentiates CXCR4 Response to CXCL12

被引：49

作者：

Carvalho Melo, Rita de Cassia ^{[1
]}

Longhini, Ana Leda ^{[1
]}

Bigarella, Carolina Louzao ^{[1
]}

Baratti, Mariana Ozello ^{[1
]}

Traina, Fabiola ^{[1
]}

Favaro, Patricia ^{[1
,2
]}

Campos, Paula de Melo ^{[1
]}

Olalla Saad, Sara Teresinha ^{[1
]}

机构：

[1] Univ Estadual Campinas, Ctr Hematol & Hemoterapia, Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Dept Ciencias Biol, Sao Paulo, Brazil

来源：

PLOS ONE | 2014年 / 9卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

CHEMOKINE RECEPTOR; CELL-MIGRATION; VASCULAR ENDOTHELIUM; BETA-ARRESTIN; CD34(+) CELLS; PROTEIN; SDF-1; CROSSTALK; SURVIVAL; BINDS;

D O I：

10.1371/journal.pone.0085926

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recently, a novel CXCL12-binding receptor, has been identified. This CXCL12-binding receptor commonly known as CXCR7 (CXC chemokine receptor 7), has lately, based on a novel nomenclature, has received the name ACKR3 (atypical chemokine receptor 3). In this study, we aimed to investigate the expression of CXCR7 in leukemic cells, as well as its participation in CXCL12 response. Interesting, we clearly demonstrated that CXCR7 is highly expressed in acute lymphoid leukemic cells compared with myeloid or normal hematopoietic cells and that CXCR7 contributed to T-acute lymphoid leukemic cell migration induced by CXCL12. Moreover, we showed that the cellular location of CXCR7 varied among T-lymphoid cells and this finding may be related to their migration capacity. Finally, we hypothesized that CXCR7 potentiates CXCR4 response and may contribute to the maintenance of leukemia by initiating cell recruitment to bone marrow niches that were once occupied by normal hematopoietic stem cells.

引用

页数：12

共 52 条

[21]

Kucia M, 2004, J MOL HISTOL, V35, P233

[22] Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis [J].

Lagane, B ;

Ballet, S ;

Planchenault, T ;

Balabanian, K ;

Le Poul, E ;

Blanpain, C ;

Percherancier, Y ;

Staropoli, I ;

Vassart, G ;

Oppermann, M ;

Parmentier, M ;

Bachelerie, F .

MOLECULAR PHARMACOLOGY, 2005, 67 (06) :1966-1976

[23] CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling [J].

Levoye, Angelique ;

Balabanian, Karl ;

Baleux, Francoise ;

Bachelerie, Francoise ;

Lagane, Bernard .

BLOOD, 2009, 113 (24) :6085-6093

[24] The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma [J].

Li, Tong ;

Li, Hui ;

Wang, Yucheng ;

Harvard, Chansonette ;

Tan, Jia-Li ;

Au, Alfred ;

Xu, Zhidong ;

Jablons, David M. ;

You, Liang .

JOURNAL OF PATHOLOGY, 2011, 223 (04) :519-530

[25] Chemokine receptors and other G protein-coupled receptors [J].

Lodowski, David T. ;

Palczewski, Krzysztof .

CURRENT OPINION IN HIV AND AIDS, 2009, 4 (02) :88-95

[26] Imaging chemokine receptor dimerization with firefly luciferase complementation [J].

Luker, Kathryn E. ;

Gupta, Mudit ;

Luker, Gary D. .

FASEB JOURNAL, 2009, 23 (03) :823-834

[27] Killing the messenger The role of CXCR7 in regulating primordial germ cell migration [J].

Mahabaleshwar, Harsha ;

Boldajipour, Bijan ;

Raz, Erez .

CELL ADHESION & MIGRATION, 2008, 2 (02) :69-70

[28] The role of stromal-derived factor-1-CXCR7 axis in development and cancer [J].

Maksym, Radoslaw B. ;

Tarnowski, Maciej ;

Grymula, Katarzyna ;

Tarnowska, Joanna ;

Wysoczynski, Marcin ;

Liu, Riu ;

Czerny, Boguslaw ;

Ratajczak, Janina ;

Kucia, Magda ;

Ratajczak, Mariusz Z. .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 625 (1-3) :31-40

[29] Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cells [J].

Mazzinghi, Benedetta ;

Ronconi, Elisa ;

Lazzeri, Elena ;

Sagrinati, Costanza ;

Ballerini, Lara ;

Angelotti, Maria Lucia ;

Parente, Eliana ;

Mancina, Rosa ;

Netti, Giuseppe Stefano ;

Becherucci, Francesca ;

Gacci, Mauro ;

Carini, Marco ;

Gesualdo, Loreto ;

Rotondi, Mario ;

Maggi, Enrico ;

Lasagni, Laura ;

Serio, Mario ;

Romagnani, Sergio ;

Romagnani, Paola .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (02) :479-490

[30] Chemokine receptor homo- or heterodimerization activates distinct signaling pathways [J].

Mellado, M ;

Rodríguez-Frade, JM ;

Vila-Coro, AJ ;

Fernández, S ;

de Ana, AM ;

Jones, DR ;

Torán, JL ;

Martínez-A, C .

EMBO JOURNAL, 2001, 20 (10) :2497-2507

← 1 2 3 4 5 6 →