Impact of vitamin D on spirometry findings and quality of life in patients with chronic obstructive pulmonary disease: a randomized, double-blinded, placebo-controlled clinical trial

被引：31
作者：
Foumani, Ali Alavi [1 ]
Mehrdad, Mojtaba [1 ,2 ]
Jafarinezhad, Alireza [1 ]
Nokani, Khadijeh [3 ]
Jafari, Alireza [1 ]
机构：
[1] Guilan Univ Med Sci, Sch Med, Razi Hosp, Inflammatory Lung Dis Res Ctr,Dept Internal Med, Sardar Jangal Ave, Rasht, Iran
[2] Guilan Univ Med Sci, Razi Clin Res Dev Ctr, Rasht, Iran
[3] Guilan Univ Med Sci, Dept Internal Med, Fac Med, Student Res Comm, Rasht, Iran
来源：
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2019年 / 14卷
关键词：
airflow obstruction; chronic; 25-hydroxyvitamin D-3; life quality; D DEFICIENCY; EXACERBATION; COPD;
D O I：
10.2147/COPD.S207400
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
COPD is an irreversible chronic illness with airflow limitation. The aim of the current study was to assess the role of vitamin D-3 on quality of life and pulmonary function in patients with COPD. A randomized, double-blinded clinical trial was conducted in 63 patients with COPD. Patients were placed into intervention and placebo groups. Each individual in the intervention group took 50,000 IU vitamin D(3)once a week for 8 weeks and then once a month for 4 months. There was no significant difference among FEV1, FEV1/FVC, and number of exacerbations in patients with COPD (P>0.05). In the intervention group, a significant difference was observed in quality of life at 2 months (P<0.001) and 6 months (P<0.001). In addition, qualitative analysis showed that the status of exacerbation had not got worse six months after initiation in the intervention group. The current study shows that consumption of 50,000 IU vitamin D-3, as a convenient supplementation in a daily diet, is able to increase quality of life in patients with COPD.
引用
收藏
页码：1495 / 1501
页数：7
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