Impact of vitamin D on spirometry findings and quality of life in patients with chronic obstructive pulmonary disease: a randomized, double-blinded, placebo-controlled clinical trial

被引：31

作者：

Foumani, Ali Alavi ^{[1
]}

Mehrdad, Mojtaba ^{[1
,2
]}

Jafarinezhad, Alireza ^{[1
]}

Nokani, Khadijeh ^{[3
]}

Jafari, Alireza ^{[1
]}

机构：

[1] Guilan Univ Med Sci, Sch Med, Razi Hosp, Inflammatory Lung Dis Res Ctr,Dept Internal Med, Sardar Jangal Ave, Rasht, Iran

[2] Guilan Univ Med Sci, Razi Clin Res Dev Ctr, Rasht, Iran

[3] Guilan Univ Med Sci, Dept Internal Med, Fac Med, Student Res Comm, Rasht, Iran

来源：

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 2019年 / 14卷

关键词：

airflow obstruction; chronic; 25-hydroxyvitamin D-3; life quality; D DEFICIENCY; EXACERBATION; COPD;

D O I：

10.2147/COPD.S207400

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

COPD is an irreversible chronic illness with airflow limitation. The aim of the current study was to assess the role of vitamin D-3 on quality of life and pulmonary function in patients with COPD. A randomized, double-blinded clinical trial was conducted in 63 patients with COPD. Patients were placed into intervention and placebo groups. Each individual in the intervention group took 50,000 IU vitamin D(3)once a week for 8 weeks and then once a month for 4 months. There was no significant difference among FEV1, FEV1/FVC, and number of exacerbations in patients with COPD (P>0.05). In the intervention group, a significant difference was observed in quality of life at 2 months (P<0.001) and 6 months (P<0.001). In addition, qualitative analysis showed that the status of exacerbation had not got worse six months after initiation in the intervention group. The current study shows that consumption of 50,000 IU vitamin D-3, as a convenient supplementation in a daily diet, is able to increase quality of life in patients with COPD.

引用

页码：1495 / 1501

页数：7

共 23 条

[1] Vitamin D analogues increase p53, p21, and apoptosis in a xenograft model of human retinoblastoma [J].