Identification of a New Delhi metallo-β-lactamase-4 (NDM-4)-producing Escherichia coli in Italy

被引：19
作者：
Coppo, Erika [1 ]
Del Bono, Valerio [2 ]
Ventura, Francesco [3 ]
Camera, Marco [2 ]
Orengo, Giovanni [4 ]
Viscoli, Claudio [5 ]
Marchese, Anna [6 ]
机构：
[1] Univ Genoa, DISC Dept, Microbiol Unit, I-16132 Genoa, Italy
[2] IRCCS AOU San Martino IST, Infect Dis Unit, I-16132 Genoa, Italy
[3] IRCCS AOU San Martino IST, Rehabilitat Unit, I-16132 Genoa, Italy
[4] IRCCS AOU San Martino IST, Hyg & Epidemiol Unit, I-16132 Genoa, Italy
[5] Univ Genoa, IRCCS AOU San Martino IST, Infect Dis Unit DISSAL, I-16132 Genoa, Italy
[6] Univ Genoa, IRCCS AOU San Martino IST, Microbiol Unit DISC, I-16132 Genoa, Italy
来源：
BMC MICROBIOLOGY | 2014年 / 14卷
关键词：
Carbapenemases; E; coli; ST405; Class; 1; integron; METALLO-BETA-LACTAMASE; OUTBREAK; ENTEROBACTERIACEAE; RESISTANCE; STRAINS; PATIENT;
D O I：
10.1186/1471-2180-14-148
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Background: During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with bla(NDM-4) gene were investigated. Results: The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and beta-lactams. The strains produced the NDM-4 carbapenemase and the bla(NDM-4) gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405). Conclusions: This is the first report on the emergence of an MDR strain of E. coli producing the NDM-4 MBL in Italy.
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页数：5
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