Porous 3-D thermoplastic polyurethane (TPU) scaffold modified with hydroxyapatite (HA) nanoparticles using an ultrasonic method

被引：11
作者：
Cui, Zhixiang [1 ,2 ]
Zheng, Zifeng [1 ,2 ]
Su, Chen [1 ,2 ]
Si, Junhui [1 ,2 ]
Wang, Qianting [1 ,2 ]
Chen, Wenzhe [1 ,2 ]
机构：
[1] Fujian Univ Technol, Sch Mat Sci & Engn, Fuzhou 350118, Fujian, Peoples R China
[2] Fujian Prov Key Lab Univ Polymer Mat & Prod, Fuzhou 350118, Fujian, Peoples R China
来源：
JOURNAL OF MATERIALS SCIENCE | 2019年 / 54卷 / 16期
基金：
中国国家自然科学基金;
关键词：
SURFACE MODIFICATION; BONE; COMPOSITE; DIFFERENTIATION; FABRICATION; NANOFIBERS; COPOLYMERS; CHITOSAN; CELLS;
D O I：
10.1007/s10853-019-03683-6
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In this work, a 3-D porous hydroxyapatite (HA)-decorated thermoplastic polyurethane (TPU) scaffold with high porosity and excellent biocompatibility was successfully fabricated using a simple ultrasonic method. It was found that HA nanoparticles were successfully introduced onto the surface of the TPU scaffold, and a strong interaction occurred between the HA nanoparticles and the TPU matrix. The porosity was calculated to be about 87%. The water contact angle decreased from 121.1 degrees for TPU to 44.6 degrees for HA-decorated TPU scaffolds. The water absorption and mechanical properties of HA-decorated TPU scaffolds were significantly higher than those of TPU scaffolds. Compared with TPU scaffolds, the addition of HA nanoparticles effectively improved the attachment and growth of mouse embryonic osteoblast cells (MC3T3-E1) cultured on the HA-decorated TPU scaffolds. These results suggest that HA-decorated TPU scaffolds possess great potential to be used as tissue engineering scaffolds. Furthermore, the ultrasonic technique could be used as a simple, effective, and universal method for decorating tissue engineering scaffolds.
引用
收藏
页码：11231 / 11242
页数：12
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