ASSOCIATION OF SINGLE NUCLEOTIDE POLYMORPHISM OF GHSR AND TGFB2 GENES WITH GROWTH AND BODY COMPOSITION TRAITS IN SIRE AND DAM LINES OF A BROILER CHICKEN

被引：19

作者：

Niarami, Mojtaba Darzi ^{[1
]}

Masoudi, Ali Akbar ^{[1
]}

Torshizi, Rasoul Vaez ^{[1
]}

机构：

[1] Tarbiat Modares Univ, Dept Anim Sci, Fac Agr, Tehran, Iran

来源：

ANIMAL BIOTECHNOLOGY | 2014年 / 25卷 / 01期

关键词：

Chicken; GHSR; Growth; Polymorphism; TGFB2; GHRELIN RECEPTOR GENE; FACTOR-BETA; CORRELATED GENES; LOCI; DIFFERENTIATION; IDENTIFICATION; APPETITE; OBESITY; WEIGHT; NUMBER;

D O I：

10.1080/10495398.2013.803478

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Growth hormone secretagogue receptor (GHSR) modulates many physiological processes by binding to its ligand, as well as transforming growth factor-beta 2 (TGFB2) regulates cell growth and development in animals and, therefore, are candidate genes for performance in chickens. In the current study, single nucleotide polymorphisms of GHSR C3286>T and TGFB2 T(-640)>C were genotyped in sire and dam lines of a broiler chicken to evaluate the association with the growth and body composition traits. Least squares means analysis showed that the GHSR C3286>T SNP was significantly (P<0.01) associated with growth (DFI and ADG) and body composition traits (AFW and %AFW). In addition, the TGFB2 T(-640)>C SNP was associated with ADG (P<0.05) and DFI and body composition traits (DW, LBW, BAKWT, %BMW, %HNDWT and %CW) (P<0.01). Significant associations of the single nucleotide polymorphisms (SNPs) on the traits reported in the present study might be the distinct usage of codons in avian, or relating to an enhancer element and modulating the expression of the gene in chicken. The data indicated that these SNPs could be valuable genetic elements for selection of chickens for better performance in the population.

引用

页码：13 / 22

页数：10

共 32 条

[1] Quantitative trait loci for performance traits in a broiler x layer cross [J].

Ambo, M. ;

Moura, A. S. A. M. T. ;

Ledur, M. C. ;

Pinto, L. F. B. ;

Baron, E. E. ;

Ruy, D. C. ;

Nones, K. ;

Campos, R. L. R. ;

Boschiero, C. ;

Burt, D. W. ;

Coutinho, L. L. .

ANIMAL GENETICS, 2009, 40 (02) :200-208

[2]

[Anonymous], 1994, NUTR REQ POULTR

[3] Polymorphisms in uncoupling protein, melanocortin 3 receptor, melanocortin 4 receptor, and pro-opiomelanocortin genes and association with production traits in a commercial broiler line [J].

Bottje, W. ;

Sharma, P. ;

Okimoto, R. .

POULTRY SCIENCE, 2008, 87 (10) :2073-2086

[4] A global search reveals epistatic interaction between QTL for early growth in the chicken [J].

Carlborg, Ö ;

Kerje, S ;

Schütz, K ;

Jacobsson, L ;

Jensen, P ;

Andersson, L .

GENOME RESEARCH, 2003, 13 (03) :413-421

[5] Associations of GHSR gene polymorphisms with chicken growth and carcass traits [J].

Fang, Meixia ;

Nie, Qinghua ;

Luo, Chenlong ;

Zhang, Dexiang ;

Zhang, Xiquan .

MOLECULAR BIOLOGY REPORTS, 2010, 37 (01) :423-428

[6] Selection on Codon Bias [J].

Hershberg, Ruth ;

Petrov, Dmitri A. .

ANNUAL REVIEW OF GENETICS, 2008, 42 :287-299

[7] The twofold difference in adult size between the red junglefowl and White Leghorn chickens is largely explained by a limited number of QTLs [J].

Kerje, S ;

Carlborg, Ö ;

Jacobsson, L ;

Schütz, K ;

Hartmann, C ;

Jensen, P ;

Andersson, L .

ANIMAL GENETICS, 2003, 34 (04) :264-274

[8]

Kocamis H, 2003, TURK J VET ANIM SCI, V27, P367

[9] Transforming growth factor-β2 enhances differentiation of cardiac myocytes from embryonic stem cells [J].

Kumar, D ;

Sun, BM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 332 (01) :135-141

[10]

LANDE R, 1981, GENETICS, V99, P541

← 1 2 3 4 →