Transmission and evolution of hepatitis C virus in HCV seroconverters in HIV infected subjects

被引：10

作者：

Shen, Chengli ^{[1
]}

Gupta, Phalguni ^{[1
]}

Xu, Xiaochuan ^{[1
]}

Sanyal, Anwesha ^{[1
]}

Rinaldo, Charles ^{[1
]}

Seaberg, Eric ^{[2
]}

Margolick, Joseph B. ^{[2
]}

Martinez-Maza, Otoniel ^{[3
]}

Chen, Yue ^{[1
]}

机构：

[1] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Infect Dis & Microbiol, Pittsburgh, PA 15261 USA

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA

来源：

VIROLOGY | 2014年 / 449卷

关键词：

HIV; HCV seroconverter; Transmission; Evolution; CD4 cell count; HUMAN-IMMUNODEFICIENCY-VIRUS; SINGLE-SOURCE OUTBREAK; VIRAL CLEARANCE; NEUTRALIZING ANTIBODIES; IMMUNE-RESPONSES; SELECTION; INDIVIDUALS; PREDICTIONS; PERSISTENCE; PROGRESSION;

D O I：

10.1016/j.virol.2013.11.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV/HCV co-infection provides a model to determine the role of immunity on HCV transmission and evolution. In this study HCV transmission and evolution were evaluated in 6 HCV seroconverters in HIV-infected subjects with a wide range of CD4 cell count. The HCV envelope E1/E2 sequences were analyzed for transmission bottleneck, viral diversity/divergence, immune pressure, and mutations of HLA class I/II restricted epitopes. HCV infection started with transmission bottleneck in all HIV-infected individuals. During the 1.0-2.0 years of infection there was a shift of viral quasispecies in majority of the subjects from one to next visit. However, HCV diversity, divergence, mutations in HLA class I/II restricted and virus neutralizing epitopes were similar in all subjects regardless of CD4 cell count at the time of HCV infection. Our results suggest that HCV transmission and evolution in HIV-infected subjects may not be influenced by host CD4 cell count at the time of infection. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：339 / 349

页数：11

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