Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case

被引：1

作者：

Adachi, Yuichi ^{[1
]}

Takimoto, Takayuki ^{[1
]}

Takeda, Maiko ^{[2
]}

Matsumoto, Kinnosuke ^{[1
]}

Takeuchi, Naoko ^{[1
]}

Kagawa, Tomoko ^{[1
]}

Sakamoto, Tetsuki ^{[3
]}

Kasai, Takahiko ^{[2
]}

Sugimoto, Chikatoshi ^{[4
]}

Inoue, Yasushi ^{[1
]}

Tachibana, Kazunobu ^{[1
,4
]}

Arai, Toru ^{[4
]}

Inoue, Yoshikazu ^{[4
]}

机构：

[1] Natl Hosp Org Kinki Chuo Chest Med Ctr, Dept Internal Med, Kita Ku, 1180 Nagasone Cho, Sakai, Osaka 5918555, Japan

[2] Natl Hosp Org Kinki Chuo Chest Med Ctr, Dept Pathol, Kita Ku, 1180 Nagasone Cho, Sakai, Osaka 5918555, Japan

[3] Natl Hosp Org Kinki Chuo Chest Med Ctr, Dept Surg, Kita Ku, 1180 Nagasone Cho, Sakai, Osaka 5918555, Japan

[4] Natl Hosp Org Kinki Chuo Chest Med Ctr, Clin Res Ctr, Kita Ku, 1180 Nagasone Cho, Sakai, Osaka 5918555, Japan

来源：

RESPIRATORY MEDICINE CASE REPORTS | 2020年 / 31卷

关键词：

Lymphoplasmacytic lymphoma; Amyloidosis; MYD88; mutation; Lymphadenopathy; Diagnosis; L265P SOMATIC MUTATION; MYD88; L265P; AL AMYLOIDOSIS; MONOCLONAL GAMMOPATHY; MACROGLOBULINEMIA; FEATURES; SUBTYPE; PROTEIN;

D O I：

10.1016/j.rmcr.2020.101313

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

A 60-year-old man was admitted for ground glass opacity in the lower lung field and mediastinal lymphadenopathy. Blood tests revealed elevated serum IgM levels, and the urine test detected Bence-Jones protein. Surgical biopsy from the mediastinal lymph node and lung showed small lymphocytes and plasma cells between follicles, and AL kappa amyloid deposition. Genetic examination detected MYD88 L265P mutation. Our diagnosis was lymphoplasmacytic lymphoma (LPL), involving the mediastinum and the lung, followed by amyloidosis. Mutation analysis, in addition to conventional histological evaluation, was useful for a precise diagnosis.

引用

页数：5

共 30 条

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