Rho GTPases Signaling in Zebrafish Development and Disease

被引：15

作者：

Boueid, Marie-Jose ^{[1
]}

Mikdache, Aya ^{[1
,2
]}

Lesport, Emilie ^{[1
]}

Degerny, Cindy ^{[1
]}

Tawk, Marcel ^{[1
]}

机构：

[1] Univ Paris Saclay, INSERM, U1195, Hop Kremlin Bicetre, F-94276 Le Kremlin Bicetre, France

[2] Inst Curie, UMR 3215, U934, F-75005 Paris, France

来源：

CELLS | 2020年 / 9卷 / 12期

关键词：

zebrafish; small GTPases; Rac; Cdc42; RhoA; GEF; GAP; IN-VIVO; DIFFERENTIAL REGULATION; NEUTROPHIL MOTILITY; PREVENTS APOPTOSIS; CELL MOTILITY; RAC1; CDC42; ACTIVATION; MIGRATION; PROTEIN;

D O I：

10.3390/cells9122634

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells encounter countless external cues and the specificity of their responses is translated through a myriad of tightly regulated intracellular signals. For this, Rho GTPases play a central role and transduce signals that contribute to fundamental cell dynamic and survival events. Here, we review our knowledge on how zebrafish helped us understand the role of some of these proteins in a multitude of in vivo cellular behaviors. Zebrafish studies offer a unique opportunity to explore the role and more specifically the spatial and temporal dynamic of Rho GTPases activities within a complex environment at a level of details unachievable in any other vertebrate organism.

引用

页数：20

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