Brain development needs sugar: the role of polysialic acid in controlling NCAM functions

被引：44

作者：

Muehlenhoff, Martina ^{[1
]}

Oltmann-Norden, Imke ^{[1
]}

Weinhold, Birgit ^{[1
]}

Hildebrandt, Herbert ^{[1
]}

Gerardy-Schahn, Rita ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Cellular Chem, OE 4330, D-30625 Hannover, Germany

来源：

BIOLOGICAL CHEMISTRY | 2009年 / 390卷 / 07期

关键词：

axon guidance; brain connectivity; cell-cell interaction; cell surface glycosylation; neural cell adhesion molecule NCAM; polysialyltransferase; CELL-ADHESION-MOLECULE; ST8SIA II STX; NERVOUS-SYSTEM; IMMUNOGLOBULIN SUPERFAMILY; OLFACTORY-BULB; COOPERATIVE POLYSIALYLATION; SIALYLTRANSFERASE FAMILY; NEURONAL DIFFERENTIATION; POLYSIALYLTRANSFERASES; ADULT HIPPOCAMPUS;

D O I：

10.1515/BC.2009.078

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polysialic acid (polySia) is a major regulator of cell-cell interactions in the developing nervous system and a key factor in maintaining neural plasticity. As a polyanionic molecule with high water binding capacity, polySia increases the intercellular space and creates conditions that are permissive for cellular plasticity. While the prevailing model highlights polySia as a non-specific regulator of cell-cell contacts, this review concentrates on recent studies in knockout mice indicating that a crucial function of polySia resides in controlling interactions mediated by its predominant protein carrier, the neural cell adhesion molecule NCAM.

引用

页码：567 / 574

页数：8

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