The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice

被引：37

作者：

Blagaic, AB ^{[1
]}

Blagaic, V ^{[1
]}

Romic, Z ^{[1
]}

Sikiric, P ^{[1
]}

机构：

[1] Univ Zagreb, Fac Med, Dept Pharmacol, Zagreb 10000, Croatia

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 499卷 / 03期

关键词：

stable gastric pentadecapeptide BPC 157; acute alcohol intoxication; withdrawal/chronic alcohol consumption;

D O I：

10.1016/j.ejphar.2004.07.112

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W1419), which was promising in inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) trials, protects against both acute and chronic alcohol-induced lesions in stomach and liver, but also, given peripherally, affects various centrally mediated disturbances. Now, in male NMRI mice BPC 157 (10 pg intraperitoneally, 10 ng and 10 mug, intraperitoneally or intragastrically) (i) strongly opposed acute alcohol (4 g/kg intraperitoneally) intoxication (i.e., quickly produced and sustained anesthesia, hypothermia, increased ethanol blood values, 25% fatality, 90-min assessment period) given before or after ethanol, and (ii) when given after abrupt cessation of ethanol (at 0 or 3 or 7 h withdrawal time), attenuated withdrawal (assessed through 24 hours) after 20%-alcohol drinking (7.6 g/kg) through 13 days, with provocation on the 14th day. (C) 2004 Published by Elsevier B.V.

引用

页码：285 / 290

页数：6

共 21 条

[1] Alcohol intoxication and withdrawal: The role of nitric oxide [J].

Adams, ML ;

Cicero, TJ .

ALCOHOL, 1998, 16 (02) :153-158

[2] Peptides: their role in excess alcohol drinking and their promise as a therapeutic tool [J].

Egli, M .

PHYSIOLOGY & BEHAVIOR, 2003, 79 (01) :89-93

[3] Chronic ethanol consumption: From neuroadaptation to neurodegeneration [J].

Fadda, F ;

Rossetti, ZL .

PROGRESS IN NEUROBIOLOGY, 1998, 56 (04) :385-431

[4]

Grogan J R, 1994, Arch Fam Med, V3, P150, DOI 10.1001/archfami.3.2.150

[5] Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats [J].

Jelovac, N ;

Sikiric, P ;

Rucman, R ;

Petek, M ;

Marovic, A ;

Perovic, D ;

Seiwerth, S ;

Mise, S ;

Turkovic, B ;

Dodig, G ;

Miklic, P ;

Buljat, G ;

Prkacin, I .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 379 (01) :19-31

[6] A novel pentadecapeptide, BPC 157, blocks the stereotypy produced acutely by amphetamine and the development of haloperidol-induced supersensitivity to amphetamine [J].

Jelovac, N ;

Sikiric, P ;

Rucman, R ;

Petek, M ;

Perovic, D ;

Konjevoda, P ;

Marovic, A ;

Seiwerth, S ;

Grabarevic, Z ;

Sumajstorcic, J ;

Dodig, G ;

Peric, J .

BIOLOGICAL PSYCHIATRY, 1998, 43 (07) :511-519

[7]

Koob G., 1983, P369

[8] Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: Reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse [J].

Lovric-Bencic, M ;

Sikiric, P ;

Hanzevacki, JS ;

Seiwerth, S ;

Rogic, D ;

Kusec, V ;

Aralica, G ;

Konjevoda, P ;

Batelja, L ;

Blagaic, AB .

JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 95 (01) :19-26

[9] Ifenprodil influences changes in mouse behaviour related to acute and chronic ethanol administration [J].

Malinowska, B ;

Napiórkowska-Pawlak, D ;

Pawlak, R ;

Buczko, W ;

Göthert, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 377 (01) :13-19

[10] The brain as an endocrine target for peptide hormones [J].

McKinley, MJ ;

Oldfield, BJ .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1998, 9 (09) :349-354

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