Investigation of the Locus Near MC4R With Childhood Obesity in Americans of European and African Ancestry

被引：64

作者：

Grant, Struan F. A. ^{[1
,2
,3
,4
]}

Bradfield, Jonathan P. ^{[1
]}

Zhang, Haitao ^{[1
]}

Wang, Kai ^{[1
]}

Kim, Cecilia E. ^{[1
]}

Annaiah, Kiran ^{[1
]}

Santa, Erin ^{[1
]}

Glessner, Joseph T. ^{[1
]}

Thomas, Kelly ^{[1
]}

Garris, Maria ^{[1
]}

Frackelton, Edward C. ^{[1
]}

Otieno, F. George ^{[1
]}

Shaner, Julie L. ^{[1
]}

Smith, Ryan M. ^{[1
]}

Imielinski, Marcin ^{[1
]}

Chiavacci, Rosetta M. ^{[1
]}

Li, Mingyao ^{[5
]}

Berkowitz, Robert I. ^{[6
,7
,8
]}

Hakonarson, Hakon ^{[1
,2
,3
,4
]}

机构：

[1] Childrens Hosp Philadelphia, Abramson Res Ctr, Ctr Appl Genom, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[3] Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

[5] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[6] Childrens Hosp Philadelphia, Behav Hlth Ctr, Philadelphia, PA 19104 USA

[7] Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat, Philadelphia, PA 19104 USA

[8] Univ Penn, Dept Psychiat, Ctr Weight & Eating Disorders, Philadelphia, PA 19104 USA

来源：

OBESITY | 2009年 / 17卷 / 07期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; FTO GENE; FAT MASS; ADULT; CHILDREN; EPIDEMIOLOGY; OVERWEIGHT; VARIANTS; RISK; TWIN;

D O I：

10.1038/oby.2009.53

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recently a modest, but consistently, replicated association was demonstrated between obesity and the single-nucleotide polymorphism (SNP), rs17782313, 3' of the MC4R locus as a consequence of a meta-analysis of genome-wide association (GWA) studies of the disease in white populations. We investigated the association in the context of the childhood form of the disease utilizing data from our ongoing GWA study in a cohort of 728 European-American (EA) obese children (BMI >= 95th percentile) and 3,960 EA controls (BMI <95th percentile), as well as 1,008 African-American (AA) obese children and 2,715 AA controls. rs571312, rs10871777, and rs476828 (perfect surrogates for rs17782313) yielded odds ratios in the EA cohort of 1.142 (P = 0.045), 1.137 (P = 0.054), and 1.145 (P = 0.042); however, there was no significant association with these SNPs in the AA cohort. When investigating all 30 SNPs present on the Illumina BeadChip at this locus, again there was no evidence for association in AA cases when correcting for the number of tests employed. As such, variants 3' to the MC4R locus present on the genotyping platform utilized confer a similar magnitude of risk of obesity in white children as to their adult white counterparts but this observation did not extend to AAs.

引用

页码：1461 / 1465

页数：5

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