MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer

被引：30
作者：
Niu, Tong [1 ,2 ,3 ]
Zhang, Weiwei [1 ,2 ]
Xiao, Wei [1 ,2 ,3 ]
机构：
[1] Capital Normal Univ, Beijing Key Lab DNA Damage Responses, Beijing 100048, Peoples R China
[2] Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
[3] Univ Saskatchewan, Dept Biochem Microbiol & Immunol, Saskatoon, SK S7N 5E5, Canada
来源：
CANCER CELL INTERNATIONAL | 2021年 / 21卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Breast cancer; Breast cancer stem cell (BCSC); miRNA; Self-renewal; Therapeutic resistance;
D O I：
10.1186/s12935-020-01716-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast cancer is the most common cancer among women and accounts for 30% of all female malignancies worldwide. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that exhibit multiple characteristics including differentiation capacity, self-renewal and therapeutic resistance. Recently, BCSCs have attracted attention due to their modulation of breast tumor behaviors and drug resistance. miRNAs are small noncoding mRNAs involved in virtually all biological processes, including stem cell development, maintenance and differentiation. In breast cancer, miRNAs appear to be multi-faceted since they can act as either suppressors or oncogenes to regulate breast cancer progression. This review summarizes the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/beta -catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the BCSC maintenance.
引用
收藏
页数：14
相关论文
共 98 条
[41]   RETRACTED: miR-221/222 enhance the tumorigenicity of human breast cancer stem cells via modulation of PTEN/Akt pathway (Retracted Article) [J].
Li, Bailong ;
Lu, Ying ;
Wang, Honghai ;
Han, Xiaocui ;
Mao, Jun ;
Li, Jiazhi ;
Yu, Lihui ;
Wang, Bo ;
Fan, Shujun ;
Yu, Xiaotang ;
Song, Bo .
BIOMEDICINE & PHARMACOTHERAPY, 2016, 79 :93-101
[42]   Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy [J].
Li, Li ;
Tang, Ping ;
Li, Shun ;
Qin, Xiang ;
Yang, Hong ;
Wu, Chunhui ;
Liu, Yiyao .
MEDICAL ONCOLOGY, 2017, 34 (10)
[43]   Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer [J].
Li, Q. ;
Yao, Y. ;
Eades, G. ;
Liu, Z. ;
Zhang, Y. ;
Zhou, Q. .
ONCOGENE, 2014, 33 (20) :2589-2600
[44]  
Li Yong-Jun, 2019, Zhongguo Shi Yan Xue Ye Xue Za Zhi, V27, P1344, DOI 10.19746/j.cnki.issn.1009-2137.2019.04.059
[45]   Breast cancer stem cells: are we ready to go from bench to bedside? [J].
Lin, Chieh-Yu ;
Barry-Holson, Keegan Q. ;
Allison, Kimberly H. .
HISTOPATHOLOGY, 2016, 68 (01) :119-137
[46]   TGFβ Induces "BRCAness" and Sensitivity to PARP Inhibition in Breast Cancer by Regulating DNA-Repair Genes [J].
Liu, Liang ;
Zhou, Weiying ;
Cheng, Chun-Ting ;
Ren, Xiubao ;
Somlo, George ;
Fong, Miranda Y. ;
Chin, Andrew R. ;
Li, Hui ;
Yu, Yang ;
Xu, Yang ;
O'Connor, Sean Timothy Francis ;
O'Connor, Timothy R. ;
Ann, David K. ;
Stark, Jeremy M. ;
Wang, Shizhen Emily .
MOLECULAR CANCER RESEARCH, 2014, 12 (11) :1597-1609
[47]   p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function [J].
Liu, Shicheng ;
Yamauchi, Hitoshi .
CANCER LETTERS, 2009, 286 (02) :240-249
[48]   MicroRNA93 Regulates Proliferation and Differentiation of Normal and Malignant Breast Stem Cells [J].
Liu, Suling ;
Patel, Shivani H. ;
Ginestier, Christophe ;
Ibarra, Ingrid ;
Martin-Trevino, Rachel ;
Bai, Shoumin ;
McDermott, Sean P. ;
Shang, Li ;
Ke, Jia ;
Ou, Sing J. ;
Heath, Amber ;
Zhang, Kevin J. ;
Korkaya, Hasan ;
Clouthier, Shawn G. ;
Charafe-Jauffret, Emmanuelle ;
Birnbaum, Daniel ;
Hannon, Gregory J. ;
Wicha, Max S. .
PLOS GENETICS, 2012, 8 (06)
[49]   CD133+ cells with cancer stem cell characteristics associates with vasculogenic mimicry in triple-negative breast cancer [J].
Liu, T. J. ;
Sun, B. C. ;
Zhao, X. L. ;
Zhao, X. M. ;
Sun, T. ;
Gu, Q. ;
Yao, Z. ;
Dong, X. Y. ;
Zhao, N. ;
Liu, N. .
ONCOGENE, 2013, 32 (05) :544-553
[50]  
Lo PK, 2012, ONCOGENE, V31, P2614, DOI [10.1038/onc.2011.439, 10.1038/onc.2012.147]
12345678910