Glucocorticoid-induced Osteoporosis

被引:109
作者
Whittier, Xena [1 ]
Saag, Kenneth G. [2 ]
机构
[1] Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Div Clin Immunol & Rheumatol,Dept Med, Ctr Educ & Res Therapeut CERTs,COERE, Ctr Res Translat CORT Gout & Hyperuricemia, Birmingham, AL 35294 USA
关键词
Glucocorticoids; Osteoporosis; Fracture risk; Prevention; CORTICOSTEROID-INDUCED OSTEOPOROSIS; LOW-DOSE PREDNISOLONE; ACTIVE RHEUMATOID-ARTHRITIS; BONE-MINERAL DENSITY; VERTEBRAL FRACTURE; DOUBLE-BLIND; POSTMENOPAUSAL WOMEN; JOINT DESTRUCTION; PREVENTION; ALENDRONATE;
D O I
10.1016/j.rdc.2015.08.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Glucocorticoid-induced osteoporosis (GIOP) is one of the most common and serious adverse effects associated with glucocorticoid use. This article highlights GIOP pathophysiology, epidemiologic associations, effective treatment, and lifestyle modifications that can reduce fracture risk for long-term glucocorticoid users and additionally emphasizes the importance of early intervention.
引用
收藏
页码:177 / +
页数:14
相关论文
共 63 条
[1]  
Adachi JD, 2001, ARTHRITIS RHEUM-US, V44, P202, DOI 10.1002/1529-0131(200101)44:1<202::AID-ANR27>3.0.CO
[2]  
2-W
[3]  
Amin S, 1999, ARTHRITIS RHEUM-US, V42, P1740, DOI 10.1002/1529-0131(199908)42:8<1740::AID-ANR25>3.0.CO
[4]  
2-E
[5]   Pharmacovigilance study of alendronate in England [J].
Biswas, PN ;
Wilton, LV ;
Shakir, SAW .
OSTEOPOROSIS INTERNATIONAL, 2003, 14 (06) :507-514
[6]   2014 update of recommendations on the prevention and treatment of glucocorticoid-induced osteoporosis [J].
Briot, Karine ;
Cortet, Bernard ;
Roux, Christian ;
Fardet, Laurence ;
Abitbol, Vered ;
Bacchetta, Justine ;
Buchon, Daniel ;
Debiais, Francoise ;
Guggenbuhl, Pascal ;
Laroche, Michel ;
Legrand, Erik ;
Lespessailles, Eric ;
Marcelli, Christian ;
Weryha, Georges ;
Thomas, Thierry .
JOINT BONE SPINE, 2014, 81 (06) :493-501
[7]   Calcium and vitamin D-3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis - A randomized, double-blind, placebo-controlled trial [J].
Buckley, LM ;
Leib, ES ;
Cartularo, KS ;
Vacek, PM ;
Cooper, SM .
ANNALS OF INTERNAL MEDICINE, 1996, 125 (12) :961-+
[8]   Elevated risk of clinical fractures and associated risk factors in patients with systemic lupus erythematosus versus matched controls: a population-based study in the United Kingdom [J].
Bultink, I. E. M. ;
Harvey, N. C. ;
Lalmohamed, A. ;
Cooper, C. ;
Lems, W. F. ;
van Staa, T. P. ;
de Vries, F. .
OSTEOPOROSIS INTERNATIONAL, 2014, 25 (04) :1275-1283
[9]   Glucocorticoid-induced osteoporosis: pathophysiology and therapy [J].
Canalis, E. ;
Mazziotti, G. ;
Giustina, A. ;
Bilezikian, J. P. .
OSTEOPOROSIS INTERNATIONAL, 2007, 18 (10) :1319-1328
[10]   Mechanisms of anabolic therapies for osteoporosis [J].
Canalis, Ernesto ;
Giustina, Andrea ;
Bilezikian, John P. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (09) :905-916