Classification Systems of Secondary Active Transporters

被引：169

作者：

Perland, Emelie ^{[1
]}

Fredriksson, Robert ^{[1
]}

机构：

[1] Uppsala Univ, Dept Pharmaceut Biosci, Mol Neuropharmacol, SE-7512 Uppsala, Sweden

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2017年 / 38卷 / 03期

基金：

瑞典研究理事会;

关键词：

SOLUTE CARRIERS; SUPERFAMILY; PROTEIN; GLUTAMINE; ABCS;

D O I：

10.1016/j.tips.2016.11.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Membrane-bound solute carrier (SLC) transporter proteins are vital to the human body, as they sustain homeostasis by moving soluble molecule as nutrients, drugs, and waste across lipid membranes. Of the 430 identified secondary active transporters in humans, 30% are still orphans, and systematic research has been requested to elaborate on their possible involvement in diseases and their potential as drug targets. To enable this, the various classification systems in use must be understood and used correctly. In this review, we describe how various classification systems for human SLCs are constructed, and how they overlap and differ. To facilitate communication between researchers and to avoid ambiguities, everyone must clearly state which classification system they are referring to when writing scientific articles.

引用

页码：305 / 315

页数：11

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