Translational Research and Functional Changes in Voiding Function in Older Adults

被引：22

作者：

Kullmann, Florenta Aura ^{[1
]}

Birder, Lori Ann ^{[1
,2
]}

Andersson, Karl-Erik ^{[3
,4
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Med, Renal Electrolyte Div, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Sch Med, Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA

[3] Wake Forest Univ, Bowman Gray Sch Med, Wake Forest Baptist Med Ctr, Dept Urol,Inst Regenerat Med, Winston Salem, NC 27157 USA

[4] Aarhus Univ, Aarhus Inst Adv Studies, DK-8000 Aarhus C, Denmark

来源：

CLINICS IN GERIATRIC MEDICINE | 2015年 / 31卷 / 04期

关键词：

Urinary bladder; Voiding dysfunctions; Ischemia; LUTS; Overactive bladder; Underactive detrusor; Urinary incontinence; Animal models; LOWER URINARY-TRACT; AGE-RELATED-CHANGES; QUALITY-OF-LIFE; CHRONICALLY ISCHEMIC BLADDER; DETRUSOR SMOOTH-MUSCLE; OVERACTIVE BLADDER; ERECTILE DYSFUNCTION; OXIDATIVE STRESS; ELDERLY-PATIENTS; PURINERGIC NEUROTRANSMISSION;

D O I：

10.1016/j.cger.2015.06.001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Age-related lower urinary tract (LUT) dysfunctions result from complex processes controlled by multiple genetic, epigenetic, and environmental factors and account for high costs of health care. This article discusses risk factors that may play a role in age-related LUT dysfunction and presents available data comparing structural and functional changes that occur with aging in the bladder of humans and animal models. A better understanding of factors and mechanisms underlying LUT symptoms in the older population may lead to therapeutic interventions to reduce these dysfunctions.

引用

页码：535 / +

页数：15

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